Rodriguez-Sierra J F, Hagley M T, Hendricks S E
Life Sci. 1986 May 19;38(20):1841-5. doi: 10.1016/0024-3205(86)90139-6.
We evaluated the effects of progesterone administration to estrogen-primed rats on licking behavior during a lick suppression test. This test assesses the behavior of water-deprived rats to lick a drinking tube for water reinforcement that is paired to electric shock. Chlordiazepoxide (a commonly used tranquilizer) is very effective in increasing licking during this test. Normal females and neonatally castrated males displayed an increase in shock-punished responses in tests conducted after hormone injections. Normal males and neonatally androgenized females were unaffected. Our results suggest that ovarian steroids, and particularly progesterone, can modulate anxiety in females and feminized males. In addition, the anxiolytic effect of progesterone appears to be mediated by a mechanism different from that of Chlordiazepoxide.
我们评估了在舔舐抑制试验中，给经雌激素预处理的大鼠注射孕酮对其舔舐行为的影响。该试验评估缺水大鼠为获取与电击配对的饮水强化而舔舐饮水管的行为。氯氮卓（一种常用的镇静剂）在该试验中能非常有效地增加舔舐行为。正常雌性大鼠和新生期阉割的雄性大鼠在激素注射后的试验中，其受电击惩罚的反应增加。正常雄性大鼠和新生期雄激素化的雌性大鼠则未受影响。我们的结果表明，卵巢甾体激素，尤其是孕酮，可以调节雌性和雌性化雄性大鼠的焦虑水平。此外，孕酮的抗焦虑作用似乎是通过一种不同于氯氮卓的机制介导的。
