a Department of Pneumology, Intensive Care and Sleep Medicine , University Hospital of Marburg and Giessen , Marburg , Germany.
b Thora Tech GmbH , Giessen , Germany.
COPD. 2017 Oct;14(5):498-503. doi: 10.1080/15412555.2017.1338681. Epub 2017 Jul 17.
Night-time respiratory symptoms have a considerable impact on sleep and life quality in patients with chronic obstructive pulmonary disease (COPD). Lack of awareness of night-time symptoms can lead to worsened COPD control. Automated long-term monitoring of respiratory symptoms with LEOSound enables assessment of nocturnal wheezing and cough.
In this observational study we investigated the prevalence and severity of cough and wheezing in patients with stable COPD [Global Initiative for Chronic Obstructive Lung Disease (GOLD) II-IV] disease for two consecutive nights with the LEOSound system. 48 patients (30 males, 63%) were eligible for inclusion, median age was 67 years, and body mass index (BMI) was 25.3 kg/m.
In 15 out of 48 patients (31%), we found wheezing periods for at least 10-minute duration. Wheezing periods >30 minutes were monitored in seven patients and wheezing periods >60 minutes were monitored in three patients. The maximum duration of wheezing was 470 minutes in one patient with COPD II. The median wheezing rate differed between the COPD stages and between active and non-active smokers. Cough was found in 42 patients (87.5%) with a range of 1-326 events. The cough-period-index in night one was 0.83 n/hour (P25:0.33||P75: 2.04) and night two 0.97 n/hour (P25:0.25||P75: 1.9). Most of the cough events were non-productive with a median of 0.86.
Night-time symptoms are common in COPD patients. LEOSound offers an opportunity to evaluate objectively night-time symptoms like wheezing and cough in patients with COPD which remain otherwise unnoticed. We found a high incidence of night-time wheezing in these patients, which was related to persistant smoking.
夜间呼吸症状对慢性阻塞性肺疾病（COPD）患者的睡眠和生活质量有重大影响。对夜间症状缺乏认识会导致 COPD 控制恶化。LEOSound 可实现对呼吸症状的自动长期监测，从而评估夜间喘息和咳嗽。
在这项观察性研究中，我们使用 LEOSound 系统连续监测两天，调查了 48 例稳定期 COPD 患者（GOLD II-IV 期）夜间咳嗽和喘息的发生率和严重程度。48 例患者中（30 名男性，占 63%）有 15 例（31%）至少有 10 分钟的喘息期，7 例患者有 >30 分钟的喘息期，3 例患者有 >60 分钟的喘息期。一名 COPD II 期患者的最长喘息时间为 470 分钟。喘息期的最大持续时间在 COPD 各期和吸烟活跃期与非活跃期之间存在差异。42 例患者（87.5%）出现咳嗽，咳嗽次数为 1-326 次。夜间 1 天的咳嗽期指数为 0.83n/h（P25：0.33||P75：2.04），夜间 2 天为 0.97n/h（P25：0.25||P75：1.9）。大多数咳嗽事件为无痰，中位数为 0.86。
夜间症状在 COPD 患者中很常见。LEOSound 为评估 COPD 患者夜间喘息和咳嗽等症状提供了机会，这些症状否则会被忽视。我们发现这些患者夜间喘息的发生率很高，这与持续吸烟有关。
