Sachweh A, von Kodolitsch Y, Kölbel T, Larena-Avellaneda A, Wipper S, Bernhardt A M, Girdauskas E, Detter C, Reichenspurner H, Blankart C R, Debus E S
Department of General and Interventional Cardiology, German Aortic Center Hamburg (DAZH), University Heart Center Hamburg, University Medical Center Hamburg Eppendorf, Martinistraße 52, 20246 Hamburg, Germany.
Department of Vascular Medicine, German Aortic Center Hamburg (DAZH), University Heart Center Hamburg, University Medical Center Hamburg Eppendorf, Hamburg, Germany.
Gefasschirurgie. 2017;22(Suppl 1):8-16. doi: 10.1007/s00772-017-0245-z. Epub 2017 Feb 7.
Guidelines summarize medical evidence, they identify the most efficient therapy under study conditions and recommend this therapy for use. The physician now has the challenge to translate a therapy that is efficient under laboratory conditions to a patient who is an individual person. To accomplish this task the physician has to make sure that (I) the ideal typical therapy is applicable and effective in this individual patient taking the special features into consideration, that (II) therapy is compliant with the norm including guidelines, laws and ethical requirements (conformity) and that (III) the therapy meets the patient's needs.
How can physicians together with the patients translate the medical evidence into an individually optimized therapy?
At the German Aortic Center in Hamburg we use I‑SWOT as an instrument to identify such individually optimized therapy. With I‑SWOT, we present an instrument with which we have developed an (I) efficient, (II) conform and (III) needs-oriented therapeutic strategy for individual patients.
I-SWOT cross-tabulates strengths (S) and weaknesses (W) related to therapy with opportunities (O) and threats (T) related to individual patients. This I‑SWOT matrix identifies four fundamental types of strategy, which comprise "SO" maximizing strengths and opportunities, "WT" minimizing weaknesses and threats, "WO" minimizing weaknesses and maximizing opportunities and "ST" maximizing strengths and minimizing threats. We discuss the case of a patient with asymptomatic thoracoabdominal aneurysm to show how I‑SWOT is used to identify an individually optimized therapy strategy.
指南总结医学证据,确定研究条件下最有效的治疗方法并推荐使用该治疗方法。现在医生面临的挑战是将实验室条件下有效的治疗方法应用于个体患者。为完成这项任务,医生必须确保:(I)考虑到特殊情况,理想的典型治疗方法适用于并对该个体患者有效;(II)治疗符合包括指南、法律和伦理要求在内的规范(合规性);(III)治疗满足患者需求。
医生如何与患者一起将医学证据转化为个体化优化治疗?
在汉堡的德国主动脉中心,我们使用I-SWOT作为确定此类个体化优化治疗的工具。通过I-SWOT,我们提出了一种工具,利用该工具我们为个体患者制定了(I)有效、(II)合规且(III)以需求为导向的治疗策略。
I-SWOT将与治疗相关的优势(S)和劣势(W)与个体患者相关的机会(O)和威胁(T)进行交叉制表。这个I-SWOT矩阵确定了四种基本策略类型,包括“SO”(最大化优势和机会)、“WT”(最小化劣势和威胁)、“WO”(最小化劣势和最大化机会)和“ST”(最大化优势和最小化威胁)。我们讨论了一名无症状胸腹主动脉瘤患者的病例,以展示如何使用I-SWOT来确定个体化优化治疗策略。