Mäkelä J P, Hilakivi I T
Pharmacol Biochem Behav. 1986 Mar;24(3):613-6. doi: 10.1016/0091-3057(86)90566-6.
Three alpha-adrenoceptor antagonists with different subtype selectivity were administered IP at the beginning of the light period of the illumination cycle to rats whose sleep-wake pattern was subsequently recorded for 12 hours. Yohimbine (1 mg/kg) initially increased active wakefulness but did not affect REM sleep. Phentolamine (10 mg/kg) and prazosin (0.5 and 1.0 mg/kg) increased the amount of REM sleep during the latter half of the light period. The mechanism of this delayed increase in REM sleep may be related to a greater extent of alpha-receptor binding as well as an optimal, moderate concentration of prazosin and phentolamine in the brain during the latter half of the light period.
在光照周期的亮期开始时，对睡眠-觉醒模式随后被记录12小时的大鼠腹腔注射三种具有不同亚型选择性的α-肾上腺素能受体拮抗剂。育亨宾（1毫克/千克）最初增加了主动觉醒，但不影响快速眼动睡眠。酚妥拉明（10毫克/千克）和哌唑嗪（0.5和1.0毫克/千克）在亮期后半段增加了快速眼动睡眠量。快速眼动睡眠这种延迟增加的机制可能在很大程度上与α-受体结合程度有关，以及在亮期后半段大脑中哌唑嗪和酚妥拉明的浓度达到最佳且适中有关。
