Turova N F, Ermolina L A, Baryshnikov V A
Zh Nevropatol Psikhiatr Im S S Korsakova. 1986;86(3):372-5.
The amino acid spectrum of blood serum was examined in 10 mentally normal children and 84 children aged 7-11 years (predominantly boys) with different degrees of intellectual deficiency (borderline intellectual deficiency, oligophrenia in the degree of debility) complicated by syndromes of motor disinhibition and torpor. Deviations in the levels of free amino acids in mentally retarded children were not very marked as is the case with hereditary enzymopathies. Most of the children had high blood concentrations of asparaginic acid and ammonia. The authors believe that children with acquired changes in the processes responsible for disposal of ammonia may be referred to a group of risk with regard to intellectual insufficiency. The results are discussed from the viewpoint of the correlation between dicarboxylic amino acids metabolism and the cycle of urea and polyamines synthesis.
对10名智力正常儿童以及84名7至11岁（以男孩为主）、患有不同程度智力缺陷（边缘智力缺陷、智力发育不全程度的智力低下）并伴有运动抑制和迟钝综合征的儿童的血清氨基酸谱进行了检查。与遗传性酶病的情况一样，智力发育迟缓儿童游离氨基酸水平的偏差并不十分明显。大多数儿童血液中天门冬氨酸和氨的浓度较高。作者认为，在氨处理过程中发生后天性变化的儿童在智力不足方面可能属于高危群体。从二羧酸氨基酸代谢与尿素和多胺合成循环之间的相关性角度对结果进行了讨论。
