Laboratory of Pharmacology and Toxicology, Department of Clinical Pharmacology, Amiens University Hospital, Amiens, France.
University of Picardie Jules Verne, INSERM U1088, Amiens, France.
Antimicrob Agents Chemother. 2017 Aug 24;61(9). doi: 10.1128/AAC.00654-17. Print 2017 Sep.
This retrospective cohort study included 53 patients admitted to the intensive care unit (ICU), with an average age of 69 years, without neurologic disorder before initiation of a continuous piperacillin infusion at the standard dose and who underwent piperacillin serum concentration monitoring. Among them, 23 developed a neurologic disorder for which the piperacillin causality was chronologically and semiologically suggestive. A concentration threshold of 157.2 mg/liter independently predicted neurotoxicity with 96.7% specificity and 52.2% sensitivity and may constitute a limitation when targeting less susceptible pathogens.
这项回顾性队列研究纳入了 53 名入住重症监护病房（ICU）的患者，平均年龄 69 岁，在开始使用标准剂量连续哌拉西林输注之前无神经功能障碍，并且进行了哌拉西林血清浓度监测。其中，23 名患者出现了神经功能障碍，哌拉西林的因果关系在时间和症状上都提示与此有关。浓度阈值为 157.2mg/L 可独立预测神经毒性，特异性为 96.7%，敏感性为 52.2%，在针对敏感性较低的病原体时可能存在局限性。
