膀胱癌中的对氧磷酶和芳基酯酶活性
Paraoxonase and arylesterase activity in bladder cancer.
作者信息
Utanğaç Mehmet Mazhar, Yeni Ercan, Savaş Murat, Altunkol Adem, Çiftçi Halil, Gümüş Kemal, Demir Mehmet
机构信息
Department of Urology, Dicle University School of Medicine, Diyarbakır, Turkey.
Department of Urology, Harran University School of Medicine, Şanlıurfa, Turkey.
出版信息
Turk J Urol. 2017 Jun;43(2):147-151. doi: 10.5152/tud.2017.89411. Epub 2017 May 3.
OBJECTIVE
Oxidative stress is the main pathogenetic mechanism in bladder cancer among many other causes. We aimed to investigate whether a potential relationship exists between bladder cancer and the activities of paraoxonase (PON1) and arylesterase (ARE) enzymes.
MATERIAL AND METHODS
The study included 56 patients with bladder cancer, and 57 healthy individuals. The relationships between enzyme activity and tumour grade, stage, muscular invasion and tumour size were evaluated. For statistical analysis, One-Sample Kolmogorov-Smirnov, Independent-T, ANOVA and Post-Hoc Bonferroni tests were used.
RESULTS
Serum levels of PON1 and ARE enzymes, and total cholesterol were significantly lower in bladder cancer group. While other lipid parameters were similar in both the patient and the control groups. Levels of ARE were positively correlated with lipid parameters except for HDL cholesterol.
CONCLUSION
Our results showed that decreased serum PON1 and ARE enzyme activities are related with tumour load and recurrence. Further studies with larger samples are needed to confirm predictive role of enzymatic activities of PON1 and ARE in the diagnosis and prognosis of bladder cancer.
目的
在膀胱癌众多致病原因中，氧化应激是主要的发病机制。我们旨在研究膀胱癌与对氧磷酶（PON1）和芳基酯酶（ARE）的活性之间是否存在潜在关系。
材料与方法
该研究纳入了56例膀胱癌患者和57名健康个体。评估了酶活性与肿瘤分级、分期、肌层浸润和肿瘤大小之间的关系。进行统计分析时，采用了单样本柯尔莫哥洛夫-斯米尔诺夫检验、独立样本t检验、方差分析和事后邦费罗尼检验。
结果
膀胱癌组血清中PON1和ARE酶水平以及总胆固醇水平显著降低。而患者组和对照组的其他血脂参数相似。ARE水平与除高密度脂蛋白胆固醇外的血脂参数呈正相关。
结论
我们的结果表明，血清PON1和ARE酶活性降低与肿瘤负荷和复发有关。需要进一步开展更大样本量的研究，以证实PON1和ARE酶活性在膀胱癌诊断和预后中的预测作用。
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