Chair of Epidemiology, University of Augsburg, University Hospital Augsburg, Stenglinstr. 2, 86156, Augsburg, Germany.
Independent Research Group Clinical Epidemiology, Helmholtz Zentrum München, German Research Centre for Environmental Health, 85764, Neuherberg, Germany.
Lipids Health Dis. 2021 Jul 31;20(1):81. doi: 10.1186/s12944-021-01508-7.
BACKGROUND: Recent studies focused on modulating factors of paraoxonase-1 (PON1) activity. In some studies the association between pro-inflammatory markers and PON1 activity was examined, but so far no population-based investigations on this issue have been conducted. The present study investigated the relationships between the pro-inflammatory markers tumor necrosis factor (TNF)-α, leptin, interleukin (IL)-6, and high-sensitive C-reactive protein (hs-CRP) and paraoxonase and arylesterase, two hydrolytic activities of PON1, in the population-based Bavarian Food Consumption Survey II. METHODS: Based on 504 participants (217 men, 287 women), the relationship between the pro-inflammatory markers and the outcomes paraoxonase and arylesterase activities were investigated using multivariable linear models. RESULTS: Circulating plasma levels of leptin (P-value < 0.0001), hs-CRP (P-value = 0.031) and IL-6 (P-value = 0.045) were significantly non-linearly associated with arylesterase activity. Leptin levels were also significantly associated with paraoxonase activity (P-value = 0.024) independently from confounding factors, including high-density lipoprotein (HDL) cholesterol. With increasing levels of these inflammatory parameters, arylesterase and paraoxonase activities increased; however, at higher levels (> 75th percentile) the activities reached a plateau or even decreased somewhat. After Bonferroni-Holm correction, only leptin remained non-linearly but significantly associated with arylesterase activity (adjusted overall P-value < 0.0001). Neither age nor sex nor obesity modified the associations. No association was found between TNF-α and paraoxonase or arylesterase activity. CONCLUSIONS: The present findings suggest that in persons with very high levels of inflammation, PON1 activity may be impaired, a fact that might subsequently be accompanied by a higher risk for cardiometabolic diseases. Whether or not the measurement of PON1 activity in combination with a lipid profile and certain inflammatory markers could improve the prediction of cardiometabolic diseases in middle-aged individuals from the general population should be evaluated in clinical studies.
背景：近期研究聚焦于对人对氧磷酶-1（PON1）活性的调节因素。部分研究检测了促炎标志物与 PON1 活性之间的相关性，但目前尚无针对这一问题的人群研究。本研究通过巴伐利亚食品消费调查 II 调查了人群中促炎标志物肿瘤坏死因子（TNF）-α、瘦素、白细胞介素（IL）-6 和高敏 C 反应蛋白（hs-CRP）与 PON1 的两种水解活性对氧磷酶和芳基酯酶之间的关系。
方法：基于 504 名参与者（217 名男性，287 名女性），使用多变量线性模型调查了促炎标志物与结局对氧磷酶和芳基酯酶活性之间的关系。
结果：循环血浆瘦素水平（P 值<0.0001）、hs-CRP（P 值=0.031）和 IL-6（P 值=0.045）与芳基酯酶活性呈显著非线性相关。瘦素水平与对氧磷酶活性也呈显著独立相关（P 值=0.024），包括高密度脂蛋白（HDL）胆固醇等混杂因素。随着这些炎症参数水平的升高，芳基酯酶和对氧磷酶活性增加；然而，在较高水平（>第 75 百分位数）时，活性达到平台期或甚至略有下降。经 Bonferroni-Holm 校正后，只有瘦素与芳基酯酶活性呈显著非线性相关（调整后的总体 P 值<0.0001）。年龄、性别或肥胖均未改变这些关联。TNF-α与对氧磷酶或芳基酯酶活性之间无相关性。
结论：本研究结果提示，在炎症水平非常高的人群中，PON1 活性可能受损，随后可能伴随着患心血管代谢疾病的风险增加。在中年人群中，是否可以通过联合测量 PON1 活性、血脂谱和某些炎症标志物来提高对心血管代谢疾病的预测，还需在临床研究中进行评估。
Scand J Clin Lab Invest. 2017-11-23
Atherosclerosis. 2008-1
J Eur Acad Dermatol Venereol. 2015-2
Metabolites. 2025-7-15
Antioxidants (Basel). 2025-2-12
Clin Exp Med. 2023-8
Int J Mol Sci. 2020-5-18
Antioxidants (Basel). 2019-8-6
Antioxidants (Basel). 2019-6-22
Ann Agric Environ Med. 2018-9-25
Crit Rev Oncol Hematol. 2018-4-26
J Am Coll Cardiol. 2018-1-2
Zotero 插件