Auerbach P S, Osterloh J, Braun O, Hu P, Geehr E C, Kizer K W, McKinney H
Ann Emerg Med. 1986 Jun;15(6):692-8. doi: 10.1016/s0196-0644(86)80427-9.
A prospective study was done to compare the efficacy of gastric emptying achieved by gastric lavage (GL) with that of ipecac-induced emesis (IE) in victims of drug overdose. Thiamine was used as a marker of recovery in gastric samples, as measured by ion exchange/ion pair high-performance liquid chromatography. There were 51 patients in the IE group and 37 in the GL group. GL produced a higher mean per cent recovery of thiamine than did IE (90% +/- 34% compared with 50% +/- 35%). There was a significant difference between the two groups (P less than .001). Recovery of thiamine was more than 70% in 28% of the IE patients, and exceeded 70% in 75% of GL patients. When gastric emptying is desired for management of the adult overdose victim, the use of GL maximizes the chance of recovering unabsorbed liquid drugs from the stomach.
开展了一项前瞻性研究，以比较洗胃（GL）和吐根诱导催吐（IE）对药物过量受害者实现胃排空的疗效。硫胺素用作胃样本中恢复情况的标志物，通过离子交换/离子对高效液相色谱法进行测定。IE组有51例患者，GL组有37例患者。GL产生的硫胺素平均回收率高于IE（分别为90%±34%和50%±35%）。两组之间存在显著差异（P<0.001）。28%的IE患者硫胺素回收率超过70%，而GL患者中有75%超过70%。当希望通过胃排空来处理成年药物过量受害者时，使用洗胃能最大程度提高从胃中回收未吸收液体药物的几率。
