McNamara R M, Aaron C K, Gemborys M, Davidheiser S
Medical College of Pennsylvania, Philadelphia 19129.
Ann Emerg Med. 1989 Sep;18(9):934-8. doi: 10.1016/s0196-0644(89)80456-1.
The traditional role of gastric emptying as the initial step in the management of the poisoned patient has recently been questioned; immediate activated charcoal administration has been recommended by some. In the setting of acetaminophen overdose, ipecac-induced emesis may interfere with subsequent oral antidotal therapy. Therefore, we conducted a study to compare the efficacy of initial therapy with ipecac with therapy with activated charcoal-cathartic in a simulated acetaminophen overdosage. Ten healthy volunteers participated in a randomized, crossover trial. Subjects ingested 3.0 g acetaminophen, followed by either no intervention, 30 mL syrup of ipecac, or 50 g activated charcoal-sorbitol solution at one hour. Serial acetaminophen levels were determined at intervals over eight hours. Both interventions significantly reduced the area under the curve compared with control (P less than .05). When comparing ipecac with activated charcoal-cathartic, no significant difference was noted among these groups.
胃排空作为中毒患者治疗初始步骤的传统作用最近受到了质疑；一些人建议立即给予活性炭。在对乙酰氨基酚过量的情况下，吐根糖浆诱导的呕吐可能会干扰随后的口服解毒治疗。因此，我们进行了一项研究，以比较在模拟对乙酰氨基酚过量时，初始使用吐根糖浆治疗与使用活性炭-泻药治疗的疗效。10名健康志愿者参与了一项随机交叉试验。受试者摄入3.0克对乙酰氨基酚，随后在1小时内不进行干预、服用30毫升吐根糖浆或50克活性炭-山梨醇溶液。在8小时内定期测定对乙酰氨基酚水平。与对照组相比，两种干预措施均显著降低了曲线下面积（P小于0.05）。在比较吐根糖浆与活性炭-泻药时，这些组之间未发现显著差异。
