胶质母细胞瘤皮肤转移：一例病例报告及文献综述
GBM skin metastasis: a case report and review of the literature.
作者信息
Lewis Gary D, Rivera Andreana L, Tremont-Lukats Ivo W, Ballester-Fuentes Leomar Y, Zhang Yi Jonathan, Teh Bin S
机构信息
Department of Radiation Oncology, Houston Methodist Hospital, Houston, TX 77030, USA.
Department of Radiation Oncology, The University of Texas Medical Branch at Galveston, Galveston, TX 77555, USA.
出版信息
CNS Oncol. 2017 Jul 18;6(3):203-9. doi: 10.2217/cns-2016-0042.
Abstract
Glioblastoma (GBM) is the most common type of malignant tumor found in the brain, and acts very aggressively by quickly and diffusely infiltrating the surrounding brain parenchyma. Despite its aggressive nature, GBM is rarely found to spread extracranially and develop distant metastases. The most common sites of these rare metastases are the lungs, pleura and cervical lymph nodes. There are also a few case reports of skin metastasis. We present the clinical, imaging and pathologic features of a case of a GBM with metastasis to the soft tissue scar and skin near the original craniotomy site. In addition, we discuss the details of this case in the context of the previously reported literature.
摘要
胶质母细胞瘤（GBM）是脑部最常见的恶性肿瘤类型，其侵袭性很强，会迅速且广泛地浸润周围脑实质。尽管具有侵袭性，但很少发现GBM会发生颅外扩散并形成远处转移。这些罕见转移的最常见部位是肺、胸膜和颈部淋巴结。也有少数皮肤转移的病例报告。我们报告了一例GBM转移至原开颅手术部位附近软组织瘢痕和皮肤的病例的临床、影像学和病理特征。此外，我们结合先前报道的文献讨论了该病例的细节。
相似文献
1
GBM skin metastasis: a case report and review of the literature.
CNS Oncol. 2017 Jul 18;6(3):203-9. doi: 10.2217/cns-2016-0042.
2
Glioblastoma multiforme metastasizing to the skin, a case report and literature review.
Radiol Case Rep. 2021 Nov 11;17(1):171-175. doi: 10.1016/j.radcr.2021.10.029. eCollection 2022 Jan.
3
A Rare Case of Glioblastoma With Extensive Liver Metastases.
Oncology (Williston Park). 2021 Nov 15;35(11):733-740. doi: 10.46883/ONC.2021.3511.0733.
4
Cervical metastatic glioblastoma multiforme.
J Coll Physicians Surg Pak. 2013 Feb;23(2):160-1.
5
Widely metastatic glioblastoma with BRCA1 and ARID1A mutations: a case report.
BMC Cancer. 2020 Jan 20;20(1):47. doi: 10.1186/s12885-020-6540-1.
6
Aggressive Brainstem Glioblastoma in a 9-Year-Old Child with Neck Node Metastases: A Case Report and Review of Literature.
J Pediatr Neurosci. 2018 Apr-Jun;13(2):234-236. doi: 10.4103/jpn.JPN_160_17.
7
Glioblastoma multiforme in skin: a report of 2 cases and review of the literature.
Am J Dermatopathol. 2008 Aug;30(4):381-4. doi: 10.1097/DAD.0b013e31817532c4.
8
Biopsy proven metastatic meningioma: A case report and review of the literature.
Rep Pract Oncol Radiother. 2019 Nov-Dec;24(6):528-532. doi: 10.1016/j.rpor.2019.08.002. Epub 2019 Aug 19.
9
A case of soft tissue metastasis from glioblastoma and review of the literature.
J Neurooncol. 2011 May;103(1):167-72. doi: 10.1007/s11060-010-0370-y. Epub 2010 Sep 1.
10
Extracranial metastasis of pediatric glioblastoma: case report and literature review.
Childs Nerv Syst. 2024 Mar;40(3):933-937. doi: 10.1007/s00381-023-06229-z. Epub 2023 Nov 20.
引用本文的文献
1
Multidisciplinary treatment is necessary in glioblastoma with extracerebral metastases.
Strahlenther Onkol. 2025 Apr;201(4):420-430. doi: 10.1007/s00066-024-02359-8. Epub 2025 Jan 22.
2
Metastatic glioblastoma to the lungs: a case report and literature review.
CNS Oncol. 2024 Jun 6;13(1):2351789. doi: 10.1080/20450907.2024.2351789. Epub 2024 Jun 12.
3
Extra-Neural Metastases of Glioblastoma: A Case Series.
Cureus. 2023 Oct 24;15(10):e47556. doi: 10.7759/cureus.47556. eCollection 2023 Oct.
4
Systemic Metastasis of Pediatric Diffuse High-grade Astrocytoma: A Case Report.
NMC Case Rep J. 2023 Oct 14;10:265-271. doi: 10.2176/jns-nmc.2023-0018. eCollection 2023.
5
Glioblastoma Multiforme With CDKN2A, Loss of PTEN and EGFR Amplification, and Diffuse Distant Organ Metastasis Treated With Six Lines of Therapy: A Case Report and Literature Review.
Cureus. 2022 Apr 3;14(4):e23796. doi: 10.7759/cureus.23796. eCollection 2022 Apr.
6
Non-coding RNAs and glioblastoma: Insight into their roles in metastasis.
Mol Ther Oncolytics. 2021 Dec 22;24:262-287. doi: 10.1016/j.omto.2021.12.015. eCollection 2022 Mar 17.
7
Glioblastoma multiforme metastasizing to the skin, a case report and literature review.
Radiol Case Rep. 2021 Nov 11;17(1):171-175. doi: 10.1016/j.radcr.2021.10.029. eCollection 2022 Jan.
8
Glioblastoma multiforme: a multi-omics analysis of driver genes and tumour heterogeneity.
Interface Focus. 2021 Jun 11;11(4):20200072. doi: 10.1098/rsfs.2020.0072. eCollection 2021 Jun.
9
Postoperative Extra-Cranial Metastasis of Glioblastoma: A Case Report.
Iran J Pathol. 2021 Winter;16(1):90-94. doi: 10.30699/ijp.2020.122780.2349. Epub 2020 Oct 10.
10
Therapeutic Targeting of Cancer Stem Cells in Human Glioblastoma by Manipulating the Renin-Angiotensin System.
Cells. 2019 Oct 31;8(11):1364. doi: 10.3390/cells8111364.
本文引用的文献
1
The 2016 World Health Organization Classification of Tumors of the Central Nervous System: a summary.
Acta Neuropathol. 2016 Jun;131(6):803-20. doi: 10.1007/s00401-016-1545-1. Epub 2016 May 9.
2
Interferon-β Modulates the Innate Immune Response against Glioblastoma Initiating Cells.
PLoS One. 2015 Oct 6;10(10):e0139603. doi: 10.1371/journal.pone.0139603. eCollection 2015.
3
Interferon-α/β enhances temozolomide activity against MGMT-positive glioma stem-like cells.
Oncol Rep. 2015 Nov;34(5):2715-21. doi: 10.3892/or.2015.4232. Epub 2015 Aug 27.
4
Extraneural metastases in glioblastoma patients: two cases with YKL-40-positive glioblastomas and a meta-analysis of the literature.
Neurosurg Rev. 2016 Jan;39(1):37-45; discussion 45-6. doi: 10.1007/s10143-015-0656-9. Epub 2015 Jul 28.
5
Interferon-β and temozolomide combination therapy for temozolomide monotherapy-refractory malignant gliomas.
Mol Clin Oncol. 2015 Jul;3(4):909-913. doi: 10.3892/mco.2015.542. Epub 2015 Apr 8.
6
Primary leptomeningeal glioblastoma with systemic metastases-case report and review of literature.
Clin Imaging. 2015 Jul-Aug;39(4):672-6. doi: 10.1016/j.clinimag.2015.03.013. Epub 2015 Apr 7.
7
An individual patient data meta-analysis on characteristics, treatments and outcomes of glioblastoma/ gliosarcoma patients with metastases outside of the central nervous system.
PLoS One. 2015 Apr 10;10(4):e0121592. doi: 10.1371/journal.pone.0121592. eCollection 2015.
8
Optimal treatment of leptomeningeal spread in glioblastoma: analysis of risk factors and outcome.
Acta Neurochir (Wien). 2015 Apr;157(4):569-76. doi: 10.1007/s00701-015-2344-5. Epub 2015 Feb 8.
9
Leptomeningeal metastases in high-grade adult glioma: development, diagnosis, management, and outcomes in a series of 34 patients.
Front Neurol. 2014 Nov 3;5:220. doi: 10.3389/fneur.2014.00220. eCollection 2014.
10
Leptomeningeal dissemination in glioblastoma; an inspection of risk factors, treatment, and outcomes at a single institution.
J Neurooncol. 2014 Dec;120(3):597-605. doi: 10.1007/s11060-014-1592-1. Epub 2014 Aug 29.
Zotero 插件