Aslan Ferit, Günaydın Elif, Yukruk Fisun, Güvenç İnanç, Gençler Onur Serdar
Department of Medical Oncology, Yüksek İhtisas University Medical Park Ankara Hospital, Ankara, TUR.
Department of Radiology, Yüksek İhtisas University Medical Park Ankara Hospital, Ankara, TUR.
Cureus. 2022 Apr 3;14(4):e23796. doi: 10.7759/cureus.23796. eCollection 2022 Apr.
In glioblastoma multiforme (GBM) cases, the tumor usually remains limited to the central nervous system in the expected disease course. Here, we discuss the case of a 41-year-old male patient who presented with extracranial spread, which has been reported in a limited number of cases in the literature. The patient received six lines of treatment including radiotherapy with temozolomide, irinotecan-bevacizumab combination, lomustine, erlotinib, everolimus, and weekly carboplatin-paclitaxel. In addition to systemic treatment, the patient underwent radiotherapy and surgery twice. Despite presenting with features consistent with a poor prognosis and extensive multi-organ metastasis, the patient achieved an overall survival of 25 months. In our view, the clinical course of our case, the follow-up, and the treatment process will add to the literature.
在多形性胶质母细胞瘤（GBM）病例中，在预期的病程中肿瘤通常局限于中枢神经系统。在此，我们讨论一例41岁男性患者出现颅外转移的病例，此类病例在文献中的报道数量有限。该患者接受了六线治疗，包括替莫唑胺放疗、伊立替康-贝伐单抗联合治疗、洛莫司汀、厄洛替尼、依维莫司以及每周一次的卡铂-紫杉醇治疗。除了全身治疗外，该患者还接受了两次放疗和手术。尽管该患者表现出预后不良和广泛多器官转移的特征，但总体生存时间达到了25个月。我们认为我们病例的临床病程、随访情况及治疗过程将丰富文献资料。
