结直肠癌中的液体活检：监测基因异质性
Liquid Biopsies in Colorectal Cancer: Monitoring Genetic Heterogeneity.
作者信息
Gargalionis Antonios N, Papavassiliou Athanasios G
机构信息
Department of Biological Chemistry, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece.
Department of Biological Chemistry, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece.
出版信息
Trends Cancer. 2017 Mar;3(3):166-168. doi: 10.1016/j.trecan.2017.01.003. Epub 2017 Jan 27.
Dynamic changes in the colorectal cancer (CRC) signalome and tumor genetic heterogeneity underlie acquired drug resistance. Improving treatment-related decisions is facilitated by an emerging consensus in the classification of tumor subtypes as well as by real-time monitoring of predictive biomarkers in circulating tumor cells and DNA.
结直肠癌（CRC）信号组的动态变化和肿瘤基因异质性是获得性耐药的基础。肿瘤亚型分类方面新出现的共识以及对循环肿瘤细胞和DNA中预测性生物标志物的实时监测，有助于改善与治疗相关的决策。
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