转运RNA修饰：癌症是否出现了摇摆现象？
tRNA Modification: Is Cancer Having a Wobble?
作者信息
Rapino Francesca, Delaunay Sylvain, Zhou Zhaoli, Chariot Alain, Close Pierre
机构信息
Laboratory of Cancer Signaling, University of Liège, 4000 Liège, Belgium; GIGA-Molecular Biology of Diseases, GIGA-Research, University of Liège, 4000 Liège, Belgium.
Laboratory of Medical Chemistry, University of Liège, 4000 Liège, Belgium; GIGA-Molecular Biology of Diseases, GIGA-Research, University of Liège, 4000 Liège, Belgium; WELBIO, Avenue Pasteur 6, 1300 Wavre, Belgium.
出版信息
Trends Cancer. 2017 Apr;3(4):249-252. doi: 10.1016/j.trecan.2017.02.004. Epub 2017 Mar 27.
Translational control of protein synthesis supports tumor development and progression to metastasis. Wobble tRNA modifications are required during translation elongation and sustain proteome homeostasis. Recent work has highlighted the surprising upregulation of the wobble uridine 34 (U34) tRNA cascade in cancer, which underlies the specific requirement for this pathway in tumor development.
蛋白质合成的翻译控制支持肿瘤的发展和向转移的进展。摆动tRNA修饰在翻译延伸过程中是必需的，并维持蛋白质组的稳态。最近的研究突出了癌症中摆动尿苷34（U34）tRNA级联的惊人上调，这是该途径在肿瘤发展中特定需求的基础。
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