Tamori Yoichiro, Deng Wu-Min
Structural Biology Center, National Institute of Genetics and Department of Genetics, School of Life Science, SOKENDAI (The Graduate University for Advanced Studies), 1111 Yata, Mishima 411-8540, Japan.
Department of Biological Science, Florida State University, Tallahassee, FL 32306-4295, USA.
Trends Cancer. 2017 Apr;3(4):259-268. doi: 10.1016/j.trecan.2017.03.003. Epub 2017 Apr 4.
Epithelial tissues are highly organized systems with a remarkable homeostatic ability to maintain morphology through regulation of cellular proliferation and tissue integrity. This robust self-organizing system is progressively disrupted during tumor development. Recent studies of conserved tumor-suppressor genes in Drosophila showed how protumor cells deviate from the robustly organized tissue microenvironment to take the first steps into becoming aggressive tumors. Here we review the 'tumor hotspot' hypothesis that explains how the tissue-intrinsic local microenvironment has a pivotal role in the initial stage of tumorigenesis in Drosophila epithelia and discuss comparable mechanisms in mammalian tissues.
上皮组织是高度有组织的系统,具有通过调节细胞增殖和组织完整性来维持形态的显著稳态能力。这个强大的自组织系统在肿瘤发展过程中会逐渐受到破坏。最近对果蝇中保守的肿瘤抑制基因的研究表明,促肿瘤细胞如何偏离高度有序的组织微环境,迈出成为侵袭性肿瘤的第一步。在这里,我们回顾了“肿瘤热点”假说,该假说解释了组织内在的局部微环境如何在果蝇上皮肿瘤发生的初始阶段发挥关键作用,并讨论了哺乳动物组织中的类似机制。