Br J Rheumatol. 1986 May;25(2):184-92.
Seventy-three patients with early, active rheumatoid arthritis (RA) were randomly allocated either to a group that received penicillamine or to a control group from which penicillamine was barred, any other second-line drug being permitted. Most (87%) of the controls received chrysotherapy at some stage. Clinical, serological and radiographic progress was observed for at least 5 years. Outcome after 5 years for the 27 remaining in the penicillamine group was compared with that for the 23 surviving controls. Both groups had improved clinically but deteriorated radiographically, with much individual variation. A subset of patients, mostly seronegative, who were radiographically normal at the outset remained so, regardless of treatment. Penicillamine was as effective as the control group treatments in relieving synovitis and as ineffective in arresting radiographic deterioration.
73例早期活动性类风湿关节炎（RA）患者被随机分为两组，一组接受青霉胺治疗，另一组为对照组，禁止使用青霉胺，但允许使用任何其他二线药物。大多数（87%）对照组患者在某个阶段接受了金疗法。对临床、血清学和影像学进展进行了至少5年的观察。将青霉胺组剩余的27例患者与23例存活的对照组患者的5年预后进行了比较。两组患者的临床症状均有改善，但影像学表现均有恶化，且个体差异较大。一部分患者，大多为血清阴性，初始时影像学正常，无论接受何种治疗，均保持正常。青霉胺在缓解滑膜炎方面与对照组治疗效果相同，在阻止影像学恶化方面同样无效。
