You Joyce H S, Choi Kin-Wing, Wong Tin-Yau, Ip Margaret, Ming Wai-Kit, Wong Rity Yee-Kwan, Chan Sze-Ngai, Tse Hoi-Tung, Chau Carrie T S, Lee Nelson L S
1 The Chinese University of Hong Kong, Shatin, Hong Kong.
2 Centre for Health Protection, Department of Health, the Government of Hong Kong SAR.
Asia Pac J Public Health. 2017 Jul;29(5):451-461. doi: 10.1177/1010539517717365.
We aimed to describe disease burden, characteristics, and outcomes of methicillin-resistant Staphylococcus aureus (MRSA) bloodstream infection (BSI) in Hong Kong. A retrospective, observational study was conducted in 26 Hong Kong public hospitals between January 2010 and December 2012. The primary outcome measures were 30-day mortality rate and infection-related hospital cost. Of 1133 patients reviewed, 727 (64.17%) were male, 1075 (94.88%) had health care-associated community-onset and 44 (3.88%) had hospital-onset MRSA infection. The mean age of patients was 76 (SD = 15) years, including 172 (15.18%) aged 20 to 59 years and 961 (84.8%) aged ≥60 years. The annual incidence rates in age groups of 20 to 59 years and ≥60 years were 0.96 to 1.148 per 100 000 and 22.7 to 24.8 per 100 000, respectively. The 30-day mortality was 367 (32.39%). Older patients (>79 years), chronic lung disease, and prior hospitalization were associated with increased mortality. The mean cost was US$10 565 (SD = 11 649; US$1 = HK$7.8). MRSA BSI was a significant burden in Hong Kong.
我们旨在描述香港耐甲氧西林金黄色葡萄球菌（MRSA）血流感染（BSI）的疾病负担、特征及转归。2010年1月至2012年12月期间，在香港26家公立医院开展了一项回顾性观察性研究。主要观察指标为30天死亡率和感染相关的住院费用。在1133例接受评估的患者中，727例（64.17%）为男性，1075例（94.88%）为医疗保健相关社区起病，44例（3.88%）为医院起病的MRSA感染。患者的平均年龄为76岁（标准差=15），其中172例（15.18%）年龄在20至59岁之间，961例（84.8%）年龄≥60岁。20至59岁年龄组和≥60岁年龄组的年发病率分别为每10万人口0.96至1.148例和每10万人口22.7至24.8例。30天死亡率为367例（32.39%）。老年患者（>79岁）、慢性肺病和既往住院与死亡率增加相关。平均费用为10565美元（标准差=11649美元；1美元=7.8港元）。MRSA BSI在香港是一项重大负担。
