Department of Paediatrics and Adolescent Medicine, University Hospital of Cologne, Cologne, Germany.
Department of Paediatrics and Adolescent Medicine, University Hospital of Cologne, Cologne, Germany.
J Reprod Immunol. 2017 Aug;122:10-13. doi: 10.1016/j.jri.2017.06.004. Epub 2017 Jul 1.
Inflammation and oxidative stress are known to increase before labour. Whether gonadal white adipose tissue (gWAT) participates in this process and whether labour-related processes in placental and adipose tissue are altered in obese women is unknown. In our mouse model, lean mice display elevated placental inflammation and oxidative stress towards the end of pregnancy, accompanied by an increased expression of pro-inflammatory factors in gWAT. Obese mice also display elevated levels of pro-inflammatory factors and oxidative stress in placentas shortly before birth. However, placental infiltration with leukocytes and an increase in gWAT pro-inflammatory factor expression in obese dams are lacking.
炎症和氧化应激已知在分娩前增加。性腺白色脂肪组织（gWAT）是否参与这一过程，以及肥胖妇女的胎盘和脂肪组织中的与分娩相关的过程是否改变尚不清楚。在我们的小鼠模型中，瘦小鼠在妊娠末期显示出升高的胎盘炎症和氧化应激，同时 gWAT 中促炎因子的表达增加。肥胖小鼠在出生前也显示出胎盘促炎因子水平升高和氧化应激增加。然而，肥胖母鼠的白细胞浸润和 gWAT 促炎因子表达的增加是缺乏的。
