Collins R K, Jackson J F, Morrison F S, Meydrech E F
South Med J. 1979 Jun;72(6):642-4, 651. doi: 10.1097/00007611-197906000-00003.
Of 72 patients with chronic myelogenous leukemia (CML), 37 were Ph1 positive, eight were negative, and 27 were not evaluated for the Ph1 chromosome. Of the 37 patients positive for Ph1, 31 had adequate evaluation. These 31 patients were reviewed for survival with reference to spleen size. Seventeen patients with spleens 3 cm or less below the left costal margin had a 50% survival of 75 months, with a mean survival of 53.9 months. Fourteen patients with spleens greater than 3 cm below the left costal margin had a 50% survival of 21 months, with a mean survival of 19 months (P = .0014). It is concluded that small splenic size in CML is associated with longer survival. It may be that this observation should be taken into consideration when considering splenectomy in the management of patients with CML.
在72例慢性粒细胞白血病（CML）患者中，37例Ph1阳性，8例阴性，27例未进行Ph1染色体评估。在37例Ph1阳性患者中，31例进行了充分评估。参照脾脏大小对这31例患者的生存情况进行了回顾。17例脾脏位于左肋缘下3厘米及以下的患者，50%的生存期为75个月，平均生存期为53.9个月。14例脾脏位于左肋缘下超过3厘米的患者，50%的生存期为21个月，平均生存期为19个月（P = 0.0014）。结论是，CML患者脾脏较小与生存期较长相关。在考虑对CML患者进行脾切除术时，可能应考虑到这一观察结果。
