Rattner B A, Clarke R N, Ottinger M A
Comp Biochem Physiol C Comp Pharmacol Toxicol. 1986;83(2):451-3. doi: 10.1016/0742-8413(86)90153-2.
To examine the effects of parathion on basal plasma luteinizing hormone (LH) concentration, male Japanese quail (Coturnix japonica) were orally intubated with 0, 5 or 10 mg/kg parathion and sacrificed after 4, 8 and 24 hr. At the 5 mg/kg dose, plasma LH levels were reduced at 4 and 8 hr, but returned to control values by 24 hr. Brain acetylcholinesterase activity was substantially reduced by 10 mg/kg parathion (52, 75 and 37% inhibition at 4, 8 and 24 hr, respectively) and plasma LH concentration remained depressed through the 24-hr period. These findings suggest that the organophosphorus insecticide parathion may alter plasma LH concentration in a manner which might impair reproductive activity, and provide indirect evidence for a cholinergic component in the regulation of LH secretion in quail.
为研究对硫磷对基础血浆促黄体生成素（LH）浓度的影响，给雄性日本鹌鹑（日本鹌鹑）经口灌胃0、5或10毫克/千克对硫磷，并在4、8和24小时后处死。在5毫克/千克剂量下，4小时和8小时时血浆LH水平降低，但到24小时时恢复到对照值。10毫克/千克对硫磷使脑乙酰胆碱酯酶活性大幅降低（在4、8和24小时时分别抑制52%、75%和37%），并且整个24小时期间血浆LH浓度持续降低。这些发现表明，有机磷杀虫剂对硫磷可能以可能损害生殖活动的方式改变血浆LH浓度，并为鹌鹑LH分泌调节中的胆碱能成分提供间接证据。
