Ray A, Chatterjee S, Ghosh S, Kabir S N, Pakrashi A, Deb C
Department of Physiology, University College of Science and Technology, Calcutta, India.
Arch Environ Contam Toxicol. 1991 Sep;21(3):383-7. doi: 10.1007/BF01060360.
Biochemical estimation of prostatic acid phosphatase and fructose content in accessory sex glands, along with radioimmunoassay of plasma gonadotrophins (FSH and LH) and testosterone were performed in Wistar rats following treatment with quinalphos, an organophosphorus insecticide, for 13 and 26 days. Prostatic acid phosphatase activity and fructose content of the accessory sex glands, and plasma levels of testosterone and FSH were significantly lower in all rats treated with quinalphos. However, the degree of inhibition was more extensive in the 26 day-treatment group who, in addition also exhibited a significant reduction in relative weights of the testes and accessory sex organs, and plasma levels of LH. All these adverse effects of quinalphos were prevented when exogenous HCG was administered in concomitant with the insecticide for 26 days. These results suggest that quinalphos may exert a suppressive effect on the functional activity of accessory sex glands by decreasing testicular testosterone production following inhibition of pituitary gonadotrophins release.
在Wistar大鼠中，用有机磷杀虫剂喹硫磷处理13天和26天后，对附属性腺中的前列腺酸性磷酸酶和果糖含量进行生化测定，并对血浆促性腺激素（促卵泡激素和促黄体生成素）和睾酮进行放射免疫测定。所有用喹硫磷处理的大鼠，其附属性腺的前列腺酸性磷酸酶活性和果糖含量以及睾酮和促卵泡激素的血浆水平均显著降低。然而，在26天治疗组中抑制程度更为广泛，该组还表现出睾丸和附属性器官相对重量以及促黄体生成素血浆水平的显著降低。当外源性人绒毛膜促性腺激素与杀虫剂同时给药26天时，喹硫磷的所有这些不良影响均得到预防。这些结果表明，喹硫磷可能通过抑制垂体促性腺激素释放后降低睾丸睾酮生成，从而对附属性腺的功能活性产生抑制作用。
