Joint Institute for High Temperatures, Russian Academy of Sciences, Moscow 125412, Russia.
Joint Institute for High Temperatures, Russian Academy of Sciences, Moscow 125412, Russia.
Trends Biotechnol. 2018 Jun;36(6):603-614. doi: 10.1016/j.tibtech.2017.06.017. Epub 2017 Jul 15.
Studies in plasma medicine, which are currently actively expanding, are of multidisciplinary character, involving physical, chemical and biological processes. Rapid progress has been achieved in this field due to synergy between experimental and theoretical/computational methods. Joint use of diagnostic tools and computations gives a better understanding of mechanisms of interaction of plasma with bio-objects. This review focuses on recent achievements in modeling of plasma for biomedical applications. Various computational approaches used in these studies are described. We discuss some results of simulations that concern the production of reactive species by plasma and their delivery to bio-objects, and we consider the effect of electroporation at direct contact of cold plasma with cells.
目前正在积极拓展的等离子体医学研究具有多学科性质,涉及物理、化学和生物过程。由于实验和理论/计算方法的协同作用,该领域取得了快速进展。联合使用诊断工具和计算可以更好地理解等离子体与生物物体相互作用的机制。本文综述了用于生物医学应用的等离子体建模的最新进展。描述了这些研究中使用的各种计算方法。我们讨论了一些涉及等离子体产生反应性物种及其向生物物体输送的模拟结果,并考虑了冷等离子体与细胞直接接触时电穿孔的影响。