泰国男男性行为者中，HIV阳性和HIV阴性者肛门活检组织及液基细胞学样本中的人乳头瘤病毒
Human papillomavirus in anal biopsy tissues and liquid-based cytology samples of HIV-positive and HIV-negative Thai men who have sex with men.
作者信息
Pankam Tippawan, Kerr Stephen J, Teeratakulpisan Nipat, Rodbamrung Piyanee, Wongkanya Rapeeporn, Keelawat Somboon, Ruangritchankul Komkrit, Hongchookiat Piranun, Watanapokasin Ramida, Phanuphak Nittaya
机构信息
The Thai Red Cross AIDS Research Centre, Bangkok, Thailand; Department of Biochemistry, Faculty of Medicine, Srinakharinwirot University, Bangkok 10110, Thailand.
HIV-NAT, Bangkok, Thailand; The Kirby Institute, University of New South Wales, Sydney, Australia.
出版信息
Papillomavirus Res. 2017 Jun;3:149-154. doi: 10.1016/j.pvr.2017.04.006. Epub 2017 May 5.
BACKGROUND
Men who have sex with men (MSM) are at high risk of developing human papillomavirus (HPV)-related anal cancer. We compared HPV genotypes in anal tissues (Bx) and anal liquid-based cytology fluid (LBC) from HIV-positive and HIV-negative MSM.
METHODS
Bx (32 normal, 41 low-grade squamous intraepithelial lesions (LSIL) and 22 high-grade squamous intraepithelial lesions (HSIL)), along with LBC from the same visit, were selected from 61 HIV-positive and 34 HIV-negative MSM who enrolled into a prospective cohort in Bangkok, Thailand. HPV genotyping was performed on Bx and LBC.
RESULTS
Any HPV and high-risk HPV (HR-HPV) prevalence were 63.2% and 60.0% in Bx and 71.6% and 62.1% in LBC, respectively. HIV-positive MSM had higher rates of HR-HPV genotypes detection (70.5% vs. 47.1%, p=0.03) in LBC than HIV-negative MSM. HPV16 (27%) was the most common HR-HPV found in HSIL tissue. In HIV-positive MSM, the frequency of HR-HPV detection increased with histopathologic grading in both Bx and LBC samples. HSIL was associated with the presence of any HR-HPV(OR 7.6 (95%CI 1.8-31.9); P=0.006) in LBC and in Bx((OR 5.6 (95%CI 1.4-22.7); P=0.02).
CONCLUSIONS
Our data strongly support the integration of HR-HPV screening on LBC samples, along with HPV vaccination, into an anal cancer prevention program.
背景
男男性行为者（MSM）患人乳头瘤病毒（HPV）相关肛门癌的风险很高。我们比较了HIV阳性和HIV阴性MSM的肛门组织（Bx）和肛门液基细胞学液（LBC）中的HPV基因型。
方法
从泰国曼谷一项前瞻性队列研究中纳入的61名HIV阳性和34名HIV阴性MSM中，选取Bx（32例正常、41例低级别鳞状上皮内病变（LSIL）和22例高级别鳞状上皮内病变（HSIL））以及同一就诊时的LBC。对Bx和LBC进行HPV基因分型。
结果
Bx中任何HPV和高危HPV（HR-HPV）的患病率分别为63.2%和60.0%，LBC中分别为71.6%和62.1%。HIV阳性MSM的LBC中HR-HPV基因型检测率（70.5%对47.1%，p = 0.03）高于HIV阴性MSM。HPV16（27%）是HSIL组织中最常见的HR-HPV。在HIV阳性MSM中，Bx和LBC样本中HR-HPV检测频率均随组织病理学分级增加。HSIL与LBC和Bx中存在任何HR-HPV相关（LBC中OR 7.6（95%CI 1.8 - 31.9）；P = 0.006），Bx中（OR 5.6（95%CI 1.4 - 22.7）；P = 0.02）。
结论
我们的数据有力支持将LBC样本的HR-HPV筛查与HPV疫苗接种纳入肛门癌预防计划。
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