荷兰阿姆斯特丹六个不同种族男性和女性的高危型人乳头瘤病毒血清流行率：HELIUS研究
High-risk human papillomavirus seroprevalence in men and women of six different ethnicities in Amsterdam, the Netherlands: The HELIUS study.
作者信息
Alberts C J, Michel A, Bruisten S, Snijder M B, Prins M, Waterboer T, Schim van der Loeff M F
机构信息
Department of Infectious Diseases Research and Prevention, Public Health Service (GGD) of Amsterdam, Amsterdam, The Netherlands; Department of Internal Medicine, Division of Infectious Diseases, Center for Infection and Immunity Amsterdam (CINIMA), Academic Medical Center (AMC), Amsterdam, The Netherlands.
Infection, Inflammation and Cancer Program, German Cancer Research Center (DKFZ), Heidelberg, Germany.
出版信息
Papillomavirus Res. 2017 Jun;3:57-65. doi: 10.1016/j.pvr.2017.01.003. Epub 2017 Feb 1.
BACKGROUND
Ethnic variations in the (sero)prevalence of Human Papillomavirus (HPV) and HPV related diseases have been observed previously. We explored if high-risk HPV (hrHPV) seropositivity indeed differs among 6 ethnic groups in Amsterdam the Netherlands and assessed if hrHPV seroprevalence is higher among women than men within each ethnic group, both after adjustment for confounders.
METHODS
From the multi-ethnic HEalthy Life In an Urban Setting (HELIUS) study in Amsterdam (the Netherlands) we randomly selected 4637 men and women aged 18-44 years with a Dutch, South-Asian Surinamese, African Surinamese, Ghanaian, Moroccan, or Turkish ethnicity. Blood samples were tested for HPV-16,-18,-31,-33,-45,-52, and -58 antibodies using a validated Luminex-based multiplex serology assay. We assessed the association of both ethnicity and gender with hrHPV seropositivity using logistic regression models with generalised estimating equations.
RESULTS
The hrHPV seroprevalence in Dutch, South-Asian Surinamese, African Surinamese, Ghanaian, Moroccan, and Turkish participants was 18%, 12%, 23%, 19%, 17%, and 15% in men, and 30%, 22%, 34%, 31%, 14%, and 15% in women, respectively. HrHPV seroprevalence of non-Dutch men did not differ significantly from Dutch men. HrHPV seroprevalence was significantly higher among African Surinamese women, and significantly lower among Moroccan and Turkish women when compared to Dutch women. These differences were not significant anymore after adjustment for demographic, health, and sexual behavioural differences between ethnicities. HrHPV seroprevalence varied by age, age of sexual debut, and lifetime sexual partners among women but not among men. Seroprevalence of hrHPV was higher among women than among men, except in the Turkish group.
CONCLUSION
Among women hrHPV seroprevalence differed by ethnicity, yet among men no pronounced differences were observed across ethnicities.
背景
先前已观察到人类乳头瘤病毒（HPV）及HPV相关疾病的（血清学）患病率存在种族差异。我们探究了荷兰阿姆斯特丹6个种族群体中高危型HPV（hrHPV）血清阳性率是否确实存在差异，并评估了在调整混杂因素后，每个种族群体中女性的hrHPV血清阳性率是否高于男性。
方法
从荷兰阿姆斯特丹的多民族城市健康生活（HELIUS）研究中，我们随机选取了4637名年龄在18 - 44岁之间、具有荷兰、南亚苏里南人、非洲苏里南人、加纳人、摩洛哥人或土耳其人种族背景的男性和女性。使用经过验证的基于Luminex的多重血清学检测法检测血液样本中的HPV - 16、- 18、- 31、- 33、- 45、- 52和- 58抗体。我们使用带有广义估计方程的逻辑回归模型评估种族和性别与hrHPV血清阳性率之间的关联。
结果
荷兰、南亚苏里南人、非洲苏里南人、加纳人、摩洛哥人和土耳其参与者中，男性的hrHPV血清阳性率分别为18%、12%、23%、19%、17%和15%，女性分别为30%、22%、34%、31%、14%和15%。非荷兰男性的hrHPV血清阳性率与荷兰男性无显著差异。与荷兰女性相比，非洲苏里南女性的hrHPV血清阳性率显著更高，而摩洛哥和土耳其女性的hrHPV血清阳性率显著更低。在调整种族之间的人口统计学、健康和性行为差异后，这些差异不再显著。女性的hrHPV血清阳性率随年龄、首次性行为年龄和终身性伴侣数量而变化，但男性中未观察到这种情况。除土耳其人群外，女性的hrHPV血清阳性率高于男性。
结论
在女性中，hrHPV血清阳性率因种族而异，但在男性中，各民族之间未观察到明显差异。
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