古巴埃及伊蚊中登革热病毒自然垂直传播的首次记录。
First record of natural vertical transmission of dengue virus in Aedes aegypti from Cuba.
作者信息
Gutiérrez-Bugallo Gladys, Rodriguez-Roche Rosmari, Díaz Gisell, Vázquez Antonio A, Alvarez Mayling, Rodríguez Magdalena, Bisset Juan A, Guzman Maria G
机构信息
Department of Vector Control, Center for Research, Diagnostic and Reference, CIDR, Institute of Tropical Medicine Pedro Kourí, PAHO-WHO Collaborating Center for Dengue and its Vector, Cuba.
Department of Virology, Center for Research, Diagnostic and Reference, CIDR, Institute of Tropical Medicine Pedro Kourí, PAHO-WHO Collaborating Center for Dengue and its Vector, Cuba.
出版信息
Acta Trop. 2017 Oct;174:146-148. doi: 10.1016/j.actatropica.2017.07.012. Epub 2017 Jul 16.
While horizontal transmission (human-mosquito-human) of dengue viruses largely determines the epidemiology of the disease, vertical transmission (infected female mosquito- infected offspring) has been suggested as a mechanism that ensures maintenance of the virus during adverse conditions for horizontal transmission to occur. The purpose of this study was to analyze the natural infection of larval stages of Aedes aegypti (Diptera: Culicidae) with the dengue virus (DENV) in Cuba. Here, we report vertical transmission of DENV-3 genotype III in natural populations of Ae. aegypti through RT-PCR detection and serotyping plus sequencing. Our report constitutes the first record of vertical transmission of DENV in Ae. aegypti from Cuba with details of its serotype and genotype.
虽然登革病毒的水平传播（人-蚊子-人）在很大程度上决定了该疾病的流行病学，但垂直传播（受感染的雌性蚊子-受感染的后代）被认为是一种在不利于水平传播发生的条件下确保病毒维持的机制。本研究的目的是分析古巴埃及伊蚊（双翅目：蚊科）幼虫阶段自然感染登革病毒（DENV）的情况。在此，我们通过逆转录聚合酶链反应（RT-PCR）检测、血清分型及测序，报告了埃及伊蚊自然种群中DENV-3基因型III的垂直传播。我们的报告是古巴埃及伊蚊中DENV垂直传播的首次记录，并详细说明了其血清型和基因型。
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