Graduate School of Science and Engineering, Yamagata University, Yonezawa, Japan.
Graduate School of Medicine, Nagoya University, Nagoya, Japan.
Sci Rep. 2017 Jul 18;7(1):5742. doi: 10.1038/s41598-017-05179-2.
We propose a multi-pinhole fluorescent x-ray computed tomography (mp-FXCT) technique for preclinical molecular imaging that can provide the complete data necessary to produce 3-D tomographic images during anaesthesia. In this method, multiple projections are simultaneously acquired through a multi-pinhole collimator with a 2-D detector and full-field volumetric beam to accelerate the data acquisition process and enhance the signal-to-noise ratios of the projections. We constructed a 15-pinhole mp-FXCT imaging system at beamline ARNE-7A at KEK and performed preliminary experiments to investigate its imaging properties using physical phantoms and a non-radioactive I imaging agent. The mp-FXCT system could detect an I concentration of 0.038 mg/ml, the minimum required for in-vivo imaging, at a spatial resolution of about 0.3 mm during a data acquisition time of 90 min, which is less than the time for which anaesthesia is effective and suggests that preclinical molecular imaging is feasible with mp-FXCT.
我们提出了一种用于临床前分子成像的多针孔荧光 X 射线计算机断层扫描（mp-FXCT）技术，该技术可以在麻醉期间提供产生 3-D 断层图像所需的完整数据。在该方法中，通过具有 2-D 探测器和全场容积束的多针孔准直器同时获取多个投影，以加速数据采集过程并提高投影的信噪比。我们在 KEK 的 ARNE-7A 光束线上构建了一个 15 针孔 mp-FXCT 成像系统，并使用物理体模和非放射性 I 成像剂进行了初步实验以研究其成像特性。mp-FXCT 系统可以在 90 分钟的数据采集时间内以约 0.3 毫米的空间分辨率检测到 0.038mg/ml 的 I 浓度，这是体内成像所需的最小浓度，这小于麻醉有效的时间，表明 mp-FXCT 可行临床前分子成像。
