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本文引用的文献

1
Testosterone, cardiovascular risk, and hormonophobia.睾酮、心血管风险和激素恐惧症。
J Sex Med. 2014 Jun;11(6):1362-6. doi: 10.1111/jsm.12556. Epub 2014 May 2.
2
Late-onset hypogonadism and mortality in aging men.老年男性迟发性性腺功能减退症与死亡率。
J Clin Endocrinol Metab. 2014 Apr;99(4):1357-66. doi: 10.1210/jc.2013-2052. Epub 2013 Dec 11.
3
In older men an optimal plasma testosterone is associated with reduced all-cause mortality and higher dihydrotestosterone with reduced ischemic heart disease mortality, while estradiol levels do not predict mortality.在老年男性中，最佳的血浆睾酮水平与全因死亡率降低有关，而较高的二氢睾酮水平与缺血性心脏病死亡率降低有关，而雌二醇水平则与死亡率无关。
J Clin Endocrinol Metab. 2014 Jan;99(1):E9-18. doi: 10.1210/jc.2013-3272. Epub 2013 Dec 20.
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Definition, classification and diagnosis of diabetes, prediabetes and metabolic syndrome.糖尿病、糖尿病前期及代谢综合征的定义、分类与诊断
Can J Diabetes. 2013 Apr;37 Suppl 1:S8-11. doi: 10.1016/j.jcjd.2013.01.011. Epub 2013 Mar 26.
5
Osteoporosis in men: an Endocrine Society clinical practice guideline.男性骨质疏松症：内分泌学会临床实践指南。
J Clin Endocrinol Metab. 2012 Jun;97(6):1802-22. doi: 10.1210/jc.2011-3045.
6
Clinical review: Endogenous testosterone and mortality in men: a systematic review and meta-analysis.临床综述：男性内源性睾酮与死亡率：系统评价和荟萃分析。
J Clin Endocrinol Metab. 2011 Oct;96(10):3007-19. doi: 10.1210/jc.2011-1137. Epub 2011 Aug 3.
7
Onset of effects of testosterone treatment and time span until maximum effects are achieved.睾酮治疗效果的出现时间和达到最大效果的时间跨度。
Eur J Endocrinol. 2011 Nov;165(5):675-85. doi: 10.1530/EJE-11-0221. Epub 2011 Jul 13.
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Adverse side effects of 5α-reductase inhibitors therapy: persistent diminished libido and erectile dysfunction and depression in a subset of patients.5α-还原酶抑制剂治疗的不良反应：一部分患者持续出现性欲减退、勃起功能障碍和抑郁。
J Sex Med. 2011 Mar;8(3):872-84. doi: 10.1111/j.1743-6109.2010.02157.x. Epub 2010 Dec 22.
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Identification of late-onset hypogonadism in middle-aged and elderly men.中老年男性迟发性性腺功能减退症的识别。
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10
Effect of long-acting testosterone treatment on functional exercise capacity, skeletal muscle performance, insulin resistance, and baroreflex sensitivity in elderly patients with chronic heart failure a double-blind, placebo-controlled, randomized study.长效睾酮治疗对老年慢性心力衰竭患者功能运动能力、骨骼肌性能、胰岛素抵抗和压力反射敏感性的影响：一项双盲、安慰剂对照、随机研究
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迟发性性腺功能减退

Late-onset hypogonadism.

作者信息

Dudek Piotr, Kozakowski Jarosław, Zgliczyński Wojciech

机构信息

Department of Endocrinology, Centre of Postgraduate Medical Education, Bielański Hospital, Warsaw, Poland.

出版信息

Prz Menopauzalny. 2017 Jun;16(2):66-69. doi: 10.5114/pm.2017.68595. Epub 2017 Jun 30.

DOI:10.5114/pm.2017.68595
PMID:28721133
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5509975/
Abstract

In Poland, the number of men over the age of 50 years exceeds 6 million. It is estimated that about 2-6% of this population develops symptoms of late-onset hypogonadism (LOH). In men, testosterone deficiency increases slightly with age. LOH is a clinically and biochemically defined disease of older men with serum testosterone level below the reference parameters of younger healthy men and with symptoms of testosterone deficiency, manifested by pronounced disturbances of quality of life and harmful effects on multiple organ systems. Testosterone replacement therapy may give several benefits regarding body composition, metabolic control, and psychological and sexual parameters.

摘要

在波兰，50岁以上男性的数量超过600万。据估计，这一人群中约有2%至6%会出现迟发性性腺功能减退（LOH）的症状。在男性中，睾酮缺乏会随着年龄的增长而略有增加。LOH是一种临床和生化定义的老年男性疾病，其血清睾酮水平低于年轻健康男性的参考参数，并伴有睾酮缺乏的症状，表现为生活质量明显受到干扰以及对多个器官系统产生有害影响。睾酮替代疗法在身体成分、代谢控制以及心理和性参数方面可能会带来诸多益处。