Ding Yu, Gao Bei-Bei, Zhou Liang, Ye Xian-Hua, Li Hong, Lai Lei, Huang Jin-Yu
Hangzhou First People's Hospital, Nanjing Medical University, Hangzhou, China.
Arch Med Sci. 2017 Jun;13(4):771-777. doi: 10.5114/aoms.2016.58713. Epub 2016 Mar 23.
Nogo-A is an important neurite growth-regulatory protein in the adult and developing nervous system. Recently, increasing evidence has shown that Nogo-A plays important roles in cardiac development and may act as a potential indicator for heart failure. In addition, increased oxidative stress has been found in individuals with cardiovascular diseases. However, not much is known regarding the expression levels of Nogo-A and reactive oxygen species (ROS) in patients with coronary heart disease (CHD). Therefore, we sought to investigate the relationship between Nogo-A, ROS levels and CHD.
The plasma Nogo-A and ROS concentrations of 122 acute coronary syndrome (ACS), 101 unstable angina pectoris (UAP), and 21 acute myocardial infarction (AMI) patients and 56 healthy controls were measured by enzyme-linked immunosorbent assay (ELISA). We further generated a receiver operating characteristic (ROC) curve to assess the diagnostic accuracy of Nogo-A and ROS in CHD.
The Nogo-A and ROS levels were significantly higher in patients with CHD than those in healthy controls. In addition, multivariate logistic regression analysis revealed that the level of Nogo-A (odds ratio (OR) = 1.624, 95% confidence interval: 1.125-2.293, = 0.009) is a risk factor for prediction of CHD. Nogo-A has diagnostic value, with an optimal threshold of 5.466 ng/ml for maximized diagnostic performance (59% sensitivity and 78.6% specificity, area under curve, < 0.05). However, ROS concentration is not a risk factor for prediction of CHD (OR = 0.999, 95% confidence interval: 0.997-1.001, = 0.320).
Increased plasma Nogo-A level may be associated with CHD.
Nogo-A是成年及发育中的神经系统中一种重要的神经突生长调节蛋白。最近，越来越多的证据表明，Nogo-A在心脏发育中发挥重要作用，可能是心力衰竭的一个潜在指标。此外，在心血管疾病患者中发现氧化应激增加。然而，关于冠心病（CHD）患者中Nogo-A和活性氧（ROS）的表达水平，人们了解得并不多。因此，我们试图研究Nogo-A、ROS水平与冠心病之间的关系。
采用酶联免疫吸附测定（ELISA）法测定122例急性冠状动脉综合征（ACS）、101例不稳定型心绞痛（UAP）、21例急性心肌梗死（AMI）患者及56例健康对照者血浆中Nogo-A和ROS的浓度。我们进一步绘制了受试者工作特征（ROC）曲线，以评估Nogo-A和ROS对冠心病的诊断准确性。
冠心病患者的Nogo-A和ROS水平显著高于健康对照者。此外，多因素逻辑回归分析显示，Nogo-A水平（比值比（OR）=1.624，95%置信区间：1.125-2.293，P=0.009）是预测冠心病的一个危险因素。Nogo-A具有诊断价值，最佳阈值为5.466 ng/ml时诊断性能最佳（灵敏度为59%，特异性为78.6%，曲线下面积，P<0.05）。然而，ROS浓度不是预测冠心病的危险因素（OR=0.999，95%置信区间：0.997-1.001，P=0.320）。
血浆Nogo-A水平升高可能与冠心病有关。
