School of Nursing, Central South University, Changsha 410013, P.R. China.
Second Honspital of Xiangya, Central South University, Changsha 410011, P.R. China.
Asian Pac J Trop Med. 2014 Jan;7(1):55-62. doi: 10.1016/S1995-7645(13)60192-3.
To investigate the alteration of plasma levels of omentin-1 and visfatin in elderly patients with coronary heart disease (CHD) and heart failure.
Plasma omentin-1 and visfatin levels were measured in 90 subjects (29 stable angina pectoris (SAP) cases, 30 unstable angina pectoris (UAP) cases and 31 age- and sex-matched healthy controls (age ≥ 60 years) by enzyme-linked immunosorbent assay methods. According to the New York Heart Association classification, 59 CHDs were divided into three groups: functional I class, 11 cases; functional II/III class, 36 cases; and functional IV class, 12 cases.
The plasma level of omentin-1 in CHD patients was significantly lower than that of the control group. Omentin-1in SAP group and UAP group were significantly lower compared to the control group (there was no statistical significance between UAP group and SAP group; P >0.05). The plasma level of visfatin in CHD patients was significantly higher than that of the control group. Similarly, visfatin in SAP group and UAP group were all significantly higher compared to the control group, while there was no statistical significance between UAP group, and SAP group. The plasma omentin-1 level was negatively correlated with SBP (r=-0.264, P<0.05), positively correlated with HDL-c level (r=0.271, P<0.05); the plasma visfatin level was positively correlated with TC (r=0.292,P<0.05), negatively correlated with HDL-c level (r=-0.266,P<0.05). There was a negative correlation between plasma omentin-1 and visfatin levels (r=-0.280, P<0.05). Moreover, multiple linear stepwise regression analysis showed that omentin-1 and visfatin levels might be affected by HDL-c level. Logistic regression analysis showed that visfatin could be an independent risk factor of CHD.
Decreased levels of omentin-1 and increased levels of visfatin may be involved in the occurrence and development of CHD. Omentin-1 and visfatin, independently, may be protective and pro-inflammatory cytokines. Additionally, both omentin-1 and visfatin may be related to lipid metabolism. Visfatin may be an independent risk factor of CHD.
探讨老年冠心病（CHD）心力衰竭患者血浆网膜素-1和内脂素水平的变化。
采用酶联免疫吸附法检测 90 例患者（29 例稳定性心绞痛（SAP）、30 例不稳定型心绞痛（UAP）和 31 例年龄和性别匹配的健康对照者（年龄≥60 岁）血浆网膜素-1和内脂素水平。根据纽约心脏病协会分级，59 例 CHD 患者分为三组：心功能Ⅰ级 11 例，心功能Ⅱ/Ⅲ级 36 例，心功能Ⅳ级 12 例。
CHD 患者血浆网膜素-1水平明显低于对照组。SAP 组和 UAP 组网膜素-1明显低于对照组（UAP 组与 SAP 组比较无统计学意义；P＞0.05）。CHD 患者血浆内脂素水平明显高于对照组。同样，SAP 组和 UAP 组内脂素水平均明显高于对照组，而 UAP 组与 SAP 组比较无统计学意义。血浆网膜素-1水平与 SBP 呈负相关（r=-0.264，P＜0.05），与 HDL-c 水平呈正相关（r=0.271，P＜0.05）；血浆内脂素水平与 TC 呈正相关（r=0.292，P＜0.05），与 HDL-c 水平呈负相关（r=-0.266，P＜0.05）。血浆网膜素-1与内脂素水平呈负相关（r=-0.280，P＜0.05）。此外，多元线性逐步回归分析表明，网膜素-1和内脂素水平可能受 HDL-c 水平的影响。Logistic 回归分析显示，内脂素可能是 CHD 的独立危险因素。
网膜素-1水平降低和内脂素水平升高可能参与 CHD 的发生发展。网膜素-1和内脂素可能是独立的保护和促炎细胞因子。此外，网膜素-1和内脂素均与脂代谢有关。内脂素可能是 CHD 的独立危险因素。
