• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

两种不同聚丙烯吊带（TVT - O和I - STOP）的结构差异和构造特征对生物相容性和组织反应没有影响。

Structural differences and architectural features of two different polypropylene slings (TVT-O and I-STOP) have no impact on biocompatibility and tissue reactions.

作者信息

Przydacz Mikolaj, Adli Oussama El Yazami, Mahfouz Wally, Loutochin Oleg, Bégin Louis R, Corcos Jacques

机构信息

Department of Urology, Jewish General Hospital, McGill University, Montreal, Quebec, Canada.

Division of Anatomical Pathology, Hôpital du Sacré-Coeur de Montréal, Montreal, Quebec, Canada.

出版信息

Cent European J Urol. 2017 Jun 30;70(2):154-162. doi: 10.5173/ceju.2017.1189. Epub 2017 Apr 14.

DOI:10.5173/ceju.2017.1189
PMID:28721282
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5510338/
Abstract

INTRODUCTION

To evaluate the impact of design features of the synthetic mid-urethral slings on tissue integrity and inflammatory responses.

MATERIAL AND METHODS

In total 30 female Sprague-Dawley rats were implanted with type I monofilamentous, macroporous polypropylene meshes: Gynecare TVT-Obturator tape (Ethicon Inc., Johnson & Johnson, Somerville, NJ, USA) and I-STOP (CL Medical Inc., Lyon, France). All animal groups were sacrificed at set time intervals - 6 weeks, 3 months, 6 months, 9 months and 12 months - and the abdominal wall was harvested with mesh strips for histological evaluation.

RESULTS

All mesh strips appeared to be well incorporated into the abdominal wall, and no signs of shrinkage was noticed. All specimens showed a thin/delicate, loose, fibrous interface between the synthetic graft plate and abdominal wall, along with mild inflammatory reactions from 6 weeks to 12 months.

CONCLUSIONS

Both mesh brands induced comparable, minimal foreign body reactions and integrated well into the host tissues despite differences in architectural features. TVT-O and I-STOP evoked similar low-grade inflammatory responses up to 12 months in this animal model. Structural differences and architectural features of polypropylene slings used in this study have had no impact on tissue integrity and inflammatory responses.

摘要

引言

评估合成尿道中段吊带的设计特征对组织完整性和炎症反应的影响。

材料与方法

总共30只雌性Sprague-Dawley大鼠植入I型单丝大孔聚丙烯网片：吉妮柔适闭孔带（美国新泽西州萨默维尔市强生公司旗下的Ethicon公司）和I-STOP（法国里昂CL Medical公司）。所有动物组在设定的时间间隔（6周、3个月、6个月、9个月和12个月）处死，并采集带有网片条的腹壁进行组织学评估。

结果

所有网片条似乎都很好地融入腹壁，未观察到收缩迹象。所有标本在合成移植物板与腹壁之间均显示出薄/细腻、疏松的纤维界面，并且从6周到12个月均伴有轻度炎症反应。

结论

尽管结构特征存在差异，但两种网片品牌引起的异物反应相当且最小，并能很好地整合到宿主组织中。在该动物模型中，吉妮柔适闭孔带和I-STOP在长达12个月的时间里引发了相似的低度炎症反应。本研究中使用的聚丙烯吊带的结构差异和构造特征对组织完整性和炎症反应没有影响。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1445/5510338/7561b241237d/CEJU-70-01189-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1445/5510338/4f6574c52768/CEJU-70-01189-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1445/5510338/6eb7593e9767/CEJU-70-01189-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1445/5510338/5b8c6bfad0f8/CEJU-70-01189-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1445/5510338/7561b241237d/CEJU-70-01189-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1445/5510338/4f6574c52768/CEJU-70-01189-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1445/5510338/6eb7593e9767/CEJU-70-01189-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1445/5510338/5b8c6bfad0f8/CEJU-70-01189-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1445/5510338/7561b241237d/CEJU-70-01189-g004.jpg

相似文献

1
Structural differences and architectural features of two different polypropylene slings (TVT-O and I-STOP) have no impact on biocompatibility and tissue reactions.两种不同聚丙烯吊带（TVT - O和I - STOP）的结构差异和构造特征对生物相容性和组织反应没有影响。
Cent European J Urol. 2017 Jun 30;70(2):154-162. doi: 10.5173/ceju.2017.1189. Epub 2017 Apr 14.
2
[Histocompatibility of an original Chinese-made mid-urethral sling in a rabbit model].[国产新型中段尿道吊带在兔模型中的组织相容性研究]
Zhonghua Fu Chan Ke Za Zhi. 2019 Jan 25;54(1):44-48. doi: 10.3760/cma.j.issn.0529-567x.2019.01.010.
3
Single-incision sling operations for urinary incontinence in women.女性尿失禁的单切口吊带手术
Cochrane Database Syst Rev. 2014 Jun 1(6):CD008709. doi: 10.1002/14651858.CD008709.pub2.
4
Tissue reactions of 5 sling materials and tissue material detachment strength of 4 synthetic mesh materials in a rabbit model.兔模型中5种吊带材料的组织反应及4种合成网片材料的组织材料分离强度
J Urol. 2005 Nov;174(5):2037-40. doi: 10.1097/01.ju.0000176478.17749.07.
5
A multicentre prospective randomised study of single-incision mini-sling (Ajust®) versus tension-free vaginal tape-obturator (TVT-O™) in the management of female stress urinary incontinence: pain profile and short-term outcomes.一项多中心前瞻性随机研究，比较单切口迷你吊带（Ajust®）与经阴道无张力吊带-闭孔器（TVT-O™）在女性压力性尿失禁治疗中的应用：疼痛特征和短期结局。
Eur J Obstet Gynecol Reprod Biol. 2012 Nov;165(1):115-21. doi: 10.1016/j.ejogrb.2012.06.022. Epub 2012 Aug 20.
6
Long-term tensile properties of tension-free vaginal tape, suprapubic arc sling system and urethral sling in an in vivo rat model.无张力阴道吊带、耻骨上弧形吊带系统及尿道吊带在大鼠体内模型中的长期拉伸特性
J Urol. 2007 Mar;177(3):1195-8. doi: 10.1016/j.juro.2006.10.030.
7
Elastic modulus for long-term evaluation of the tensile properties of polypropylene meshes in an in vivo rat model.用于在体内大鼠模型中对聚丙烯网片拉伸性能进行长期评估的弹性模量。
Acta Bioeng Biomech. 2017;19(4):153-160.
8
Outcomes of Retropubic Synthetic Midurethral Gynecare TVT Slings When Performed by Urogynecologists, Urologists, and General Gynecologists in a Private Community Hospital.在一家私立社区医院，由泌尿妇科医生、泌尿科医生和普通妇科医生实施耻骨后合成材料中尿道吉妮环悬吊术的结果。
Female Pelvic Med Reconstr Surg. 2010 Jul;16(4):238-41. doi: 10.1097/SPV.0b013e3181dffea9.
9
Obturator Neuralgia: A Rare Complication of Tension-free Vaginal Tape Sling-Complete Resolution After Laparoscopic Tension-free Vaginal Tape Removal.闭孔神经痛：无张力阴道吊带术的一种罕见并发症——腹腔镜下取出无张力阴道吊带后完全缓解
J Minim Invasive Gynecol. 2015 May-Jun;22(4):548. doi: 10.1016/j.jmig.2015.02.015. Epub 2015 Feb 28.
10
New surgical technique for treatment of stress urinary incontinence TVT-ABBREVO from development to clinical experience.治疗压力性尿失禁的新手术技术TVT-ABBREVO：从研发到临床经验
Surg Technol Int. 2012 Dec;22:149-57.

本文引用的文献

1
In vivo response to polypropylene following implantation in animal models: a review of biocompatibility.动物模型植入后聚丙烯的体内反应：生物相容性综述
Int Urogynecol J. 2017 Feb;28(2):171-180. doi: 10.1007/s00192-016-3029-1. Epub 2016 May 23.
2
Host response to synthetic mesh in women with mesh complications.患有网片并发症的女性对合成网片的宿主反应。
Am J Obstet Gynecol. 2016 Aug;215(2):206.e1-8. doi: 10.1016/j.ajog.2016.04.008. Epub 2016 Apr 16.
3
Biomechanical and morphological study of a new elastic mesh (Ciberlastic) to repair abdominal wall defects.
一种用于修复腹壁缺损的新型弹性网片（Ciberlastic）的生物力学与形态学研究
J Mech Behav Biomed Mater. 2016 Jun;59:366-378. doi: 10.1016/j.jmbbm.2016.02.010. Epub 2016 Feb 10.
4
Evaluating Alternative Materials for the Treatment of Stress Urinary Incontinence and Pelvic Organ Prolapse: A Comparison of the In Vivo Response to Meshes Implanted in Rabbits.评估治疗压力性尿失禁和盆腔器官脱垂的替代材料：比较在兔体内植入的网片的体内反应。
J Urol. 2016 Jul;196(1):261-9. doi: 10.1016/j.juro.2016.02.067. Epub 2016 Feb 13.
5
Immediate postoperative changes in synthetic meshes - In vivo measurements.合成补片的术后即刻变化——体内测量
J Mech Behav Biomed Mater. 2015 Mar;55:228-235. doi: 10.1016/j.jmbbm.2015.10.015. Epub 2015 Oct 30.
6
In vivo biomechanical properties of heavy versus light weight monofilament polypropylene meshes. Does the knitting pattern matter?重质与轻质单丝聚丙烯网片的体内生物力学特性。编织方式有影响吗？
Neurourol Urodyn. 2017 Jan;36(1):73-79. doi: 10.1002/nau.22890. Epub 2015 Oct 5.
7
Management of complications of mesh surgery.补片手术并发症的管理。
Curr Opin Urol. 2015 Jul;25(4):284-91. doi: 10.1097/MOU.0000000000000187.
8
[Seven-year follow-up of 331 I-Stop transobturator sling cases in female urinary incontinence treatment].[331例I-Stop经闭孔吊带治疗女性尿失禁的七年随访]
Prog Urol. 2014 Oct;24(12):750-6. doi: 10.1016/j.purol.2014.07.001. Epub 2014 Jul 30.
9
Characterizing the ex vivo mechanical properties of synthetic polypropylene surgical mesh.表征合成聚丙烯外科补片的体外力学性能。
J Mech Behav Biomed Mater. 2014 Sep;37:48-55. doi: 10.1016/j.jmbbm.2014.05.005. Epub 2014 May 11.
10
Coating with autologous plasma improves biocompatibility of mesh grafts in vitro: development stage of a surgical innovation.自体血浆涂层可提高体外网片移植物的生物相容性：外科创新的开发阶段。
Biomed Res Int. 2013;2013:536814. doi: 10.1155/2013/536814. Epub 2013 Sep 17.