The Warren and Katharine Schlinger Laboratory for Chemistry and Chemical Engineering, Division of Chemistry and Chemical Engineering, California Institute of Technology, 1200 E. California Blvd, MC 101-20, Pasadena, CA, 91125, USA.
Angew Chem Int Ed Engl. 2017 Sep 11;56(38):11545-11548. doi: 10.1002/anie.201707015. Epub 2017 Aug 9.
The first highly enantioselective iridium-catalyzed allylic alkylation that provides access to products bearing an allylic all-carbon quaternary stereogenic center has been developed. The reaction utilizes a masked acyl cyanide (MAC) reagent, which enables the one-pot preparation of α-quaternary carboxylic acids, esters, and amides with a high degree of enantioselectivity. The utility of these products is further explored through a series of diverse product transformations.
首次发展了一种高对映选择性的铱催化烯丙基烷基化反应,可获得具有烯丙基全碳季立体中心的产物。该反应利用了掩蔽的酰基氰化物(MAC)试剂,可实现α-季碳羧酸、酯和酰胺的一锅法制备,具有高度的对映选择性。通过一系列不同的产物转化进一步探索了这些产物的用途。