State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences , 345 Lingling Road, Shanghai 200032, P. R. China.
Org Lett. 2016 Oct 7;18(19):5094-5097. doi: 10.1021/acs.orglett.6b02540. Epub 2016 Sep 13.
Asymmetric allylation of aldehydes with γ-disubstituted allyl halides has been achieved in the presence of a sulfonamide/oxazoline chromium complex. A variety of synthetically useful α-homoallylic alcohols with two consecutive stereogenic centers, including one quaternary carbon, can be accessed in a highly diastereoselective and enantioselective manner.
在磺酰胺/恶唑啉铬配合物的存在下，实现了γ-取代烯丙基卤代物与醛的不对称烯丙基化反应。通过这种方法，可以高非对映选择性和对映选择性地获得多种具有两个连续手性中心的合成有用的α-高烯丙基醇，包括一个季碳原子。
