从桑叶（桑属白桑种）中分离的化合物对3T3-L1脂肪细胞的脂解作用。

Lipolytic effect of compounds isolated from leaves of mulberry (Morus alba L.) in 3T3-L1 adipocytes.

作者信息

Li Hong Xu, Jo Eunji, Myung Chang-Seon, Kim Young Ho, Yang Seo Young

机构信息

a College of Pharmacy , Chungnam National University , Daejeon , Korea.

出版信息

Nat Prod Res. 2018 Aug;32(16):1963-1966. doi: 10.1080/14786419.2017.1354190. Epub 2017 Jul 19.

DOI:10.1080/14786419.2017.1354190

PMID:28722505

Abstract

In this study, 19 known compounds were isolated from mulberry (Morus alba L.) leaves. The lipid accumulation inhibitory activity of the isolated compounds was investigated. Compounds 4 and 12 showed good anti-adipogenic activity based on 3T3-L1 adipocytes with values of 36.6 ± 9.0 and 34.7 ± 4.0%, respectively. In addition, compounds 3, 6 and 15 showed significant inhibitory activity with values from 15.4 to 21.2% and compounds 2, 8-9 and 17-18 exhibited weak activity with values ranging from 2.1 to 10.7% at a concentration of 40.0 μM. These results show the potentiality that mulberry leaf is an excellent inhibitory phytochemical source against lipid accumulation.

摘要

在本研究中，从桑叶（桑科植物桑）中分离出19种已知化合物。对分离出的化合物的脂质积累抑制活性进行了研究。基于3T3-L1脂肪细胞，化合物4和12表现出良好的抗脂肪生成活性，其抑制率分别为36.6±9.0%和34.7±4.0%。此外，化合物3、6和15表现出显著的抑制活性，抑制率在15.4%至21.2%之间，而化合物2、8 - 9和17 - 18在40.0μM浓度下表现出较弱的活性，抑制率在2.1%至10.7%之间。这些结果表明桑叶具有作为抗脂质积累的优良植物化学抑制剂来源的潜力。