Kerschner J H, Calisher C H, Vorndam A V, Francy D B
J Gen Virol. 1986 Jun;67 ( Pt 6):1081-9. doi: 10.1099/0022-1317-67-6-1081.
Sixteen virus isolates with similar biological characteristics were obtained from salt-marsh mosquitoes collected in south Texas in 1974. When compared antigenically, these and 13 other isolates from mosquitoes collected between 1972 and 1979 in west Texas, New Mexico, Louisiana, Colorado and North Dakota were shown to be related but not identical. Three distinct serotypes were determined: Bahia Grande (prototype strain TB4-1054), Reed Ranch (TB4-222) and Muir Springs (76V-23524). When examined by electron microscopy, these three viruses were shown to be rhabdoviruses. Structural analysis of the prototype strain of Bahia Grande virus from Texas revealed five proteins. Comparative oligonucleotide fingerprint maps showed 51 to 86% sharing of the large oligonucleotides between Bahia Grande virus (strain TB4-1054) and 11 other antigenically related isolates but not with Muir Springs virus (strain 76V-23524), an antigenically distinct isolate from mosquitoes collected in Colorado. A serological survey for antibody to Bahia Grande virus showed that humans, cattle, sheep, reptiles and wild mammals from south Texas had neutralizing antibodies to this virus.
1974年，从得克萨斯州南部采集的盐沼蚊中获得了16株具有相似生物学特性的病毒分离株。在抗原性比较时，发现这些分离株以及1972年至1979年间从得克萨斯州西部、新墨西哥州、路易斯安那州、科罗拉多州和北达科他州采集的蚊中分离出的其他13株病毒存在相关性，但并不完全相同。确定了三种不同的血清型：巴伊亚格兰德（原型株TB4 - 1054）、里德牧场（TB4 - 222）和缪尔泉（76V - 23524）。通过电子显微镜检查，这三种病毒均为弹状病毒。对来自得克萨斯州的巴伊亚格兰德病毒原型株的结构分析显示有五种蛋白质。比较寡核苷酸指纹图谱表明，巴伊亚格兰德病毒（株TB4 - 1054）与其他11株抗原相关的分离株之间，大寡核苷酸的共享率为51%至86%，但与缪尔泉病毒（株76V - 23524）不同，缪尔泉病毒是从科罗拉多州采集的蚊中分离出的抗原性不同的分离株。一项针对巴伊亚格兰德病毒抗体的血清学调查显示，得克萨斯州南部的人类、牛、羊、爬行动物和野生哺乳动物对该病毒具有中和抗体。
