Richardson Sharise, Seekaew Pich, Koblin Beryl, Vazquez Tasha, Nandi Vijay, Tieu Hong-Van
University of Miami School of Medicine, Miami, Florida, United States of America.
Department of Prevention, Thai Red Cross AIDS Research Center, Bangkok, Thailand.
PLoS One. 2017 Jul 19;12(7):e0181702. doi: 10.1371/journal.pone.0181702. eCollection 2017.
Black men who have sex with men (MSM), and Transwomen (TW) shoulder disproportionate burden of HIV. However, they are unrepresented in HIV vaccine trials. We investigated the perceptions of that factors associated with HIV vaccine trials participation among Black MSM and TW in New York.
Self-administered online questionnaires were administered to 18-29 years of NYC residents who identified as Black MSM and TW, assessing demographics, awareness and willingness to participate in HIV vaccine trials, barriers and facilitators associated with willingness, and sexual behaviors. Frequency summation was performed to determine barriers and facilitators, and logistic regression analysis was performed to determine factors association with expressed willingness.
Black MSM and TW who reported engaging in risk behaviors had a 61% lower likelihood of participating in HIV vaccine trials when compared to those who did not report engaging in any risk behavior. Facilitators associated with trial participation were: cash compensation, confidentiality regarding participation, public transportation vouchers, gift cards, and food or grocery vouchers as potential facilitators for trial participation. Conversely, fear of side effects from the vaccine, concerns about testing positive on routine HIV testing due to an HIV vaccine, limited knowledge of research trials, and fear of being judged as HIV-positive were perceived as barriers.
These findings provided insights into the considerations and perceptions of Black MSM and TW towards HIV vaccine trials. However, further studies are needed to delineate the complex mechanisms underlying the decision-making process and establish approaches to increase study participation in this population.
与男性发生性关系的黑人男性（男男性行为者）和跨性别女性承担着不成比例的艾滋病毒负担。然而，他们在艾滋病毒疫苗试验中没有得到体现。我们调查了纽约男男性行为黑人与跨性别女性对参与艾滋病毒疫苗试验相关因素的看法。
对18至29岁、自认为是男男性行为黑人与跨性别女性的纽约市居民进行在线自填问卷调查，评估人口统计学特征、对参与艾滋病毒疫苗试验的知晓度和意愿、与意愿相关的障碍和促进因素以及性行为。进行频率汇总以确定障碍和促进因素，并进行逻辑回归分析以确定与表达意愿相关的因素。
与未报告有任何风险行为的人相比，报告有风险行为的男男性行为黑人与跨性别女性参与艾滋病毒疫苗试验的可能性低61%。与试验参与相关的促进因素包括：现金补偿、参与的保密性、公共交通代金券、礼品卡以及食品或杂货代金券等作为试验参与的潜在促进因素。相反，对疫苗副作用的恐惧、对因艾滋病毒疫苗导致常规艾滋病毒检测呈阳性的担忧、对研究试验的了解有限以及担心被判定为艾滋病毒阳性被视为障碍。
这些发现为男男性行为黑人与跨性别女性对艾滋病毒疫苗试验的考虑和看法提供了见解。然而，需要进一步研究来阐明决策过程背后的复杂机制，并建立增加该人群参与研究的方法。
