Chu Zhenxing, Xu Junjie, Reilly Kathleen Heather, Lu Chunming, Hu Qinghai, Ma Ning, Zhang Min, Zhang Jing, Jiang Yongjun, Geng Wenqing, Shang Hong
Key Laboratory of AIDS Immunology of Ministry of Health, Department of Laboratory Medicine, The First Hospital of China Medical University, Shenyang 110001, China ; Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Hangzhou 310000, China.
National Center for AIDS/STD Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China.
Biomed Res Int. 2013;2013:493128. doi: 10.1155/2013/493128. Epub 2013 Nov 25.
The number of new HIV infections among MSM of China is rapidly increasing in recent years and behavioral interventions have had limited effectiveness. To control the HIV pandemic may lie in an HIV vaccine. This study examined the factors associated with willingness to participate (WTP) in HIV vaccine clinical trials among China MSM.
A cross-sectional survey was carried out among MSM from three cities in northeast China. Questionnaires pertaining to MSM risk behavior and WTP in HIV vaccine trials were administered through computer assisted self-interviewing (CASI).
A total of 626 MSM participated in this survey. 54.8% had occasional male partners and 52.2% always used condoms with male sex partners. HIV prevalence was 5.0%. 76.7% were WTP in a preventive HIV vaccine clinical trial. Results showed that HIV vaccination is a means of protection for spouses and family; family support to participate in vaccine trials and desire for economic incentives were significantly associated with WTP.
There was a high proportion of WTP in HIV vaccine trials among Chinese MSM. The high HIV prevalence and high proportion of risky sexual behavior indicate that Liaoning MSM are potential candidates for HIV vaccine trials.
近年来，中国男男性行为者（MSM）中新发艾滋病毒感染人数迅速增加，行为干预效果有限。控制艾滋病毒大流行可能在于研制艾滋病毒疫苗。本研究调查了中国男男性行为者中与参与艾滋病毒疫苗临床试验意愿（WTP）相关的因素。
对中国东北三个城市的男男性行为者进行了横断面调查。通过计算机辅助自我访谈（CASI）发放了有关男男性行为者风险行为和艾滋病毒疫苗试验参与意愿的问卷。
共有626名男男性行为者参与了本次调查。54.8%的人有偶尔的男性伴侣，52.2%的人在与男性性伴侣发生性行为时始终使用避孕套；艾滋病毒感染率为5.0%。76.7%的人愿意参与预防性艾滋病毒疫苗临床试验。结果表明，艾滋病毒疫苗接种是保护配偶和家人的一种方式；家人对参与疫苗试验的支持以及对经济激励的渴望与参与意愿显著相关。
中国男男性行为者中愿意参与艾滋病毒疫苗试验的比例较高。艾滋病毒高感染率和高比例的危险行为表明，辽宁的男男性行为者是艾滋病毒疫苗试验的潜在对象。
