增强型光动力疗法的最新进展：从新机制到创新策略。
Recent advances for enhanced photodynamic therapy: from new mechanisms to innovative strategies.
作者信息
Wang Xia, Peng Jinlei, Meng Chi, Feng Fude
机构信息
MOE Key Laboratory of High Performance Polymer Materials and Technology, Department of Polymer Science & Engineering, School of Chemistry & Chemical Engineering, Nanjing University Nanjing 210023 China
出版信息
Chem Sci. 2024 Jul 12;15(31):12234-12257. doi: 10.1039/d3sc07006a. eCollection 2024 Aug 7.
Photodynamic therapy (PDT) has been developed as a potential cancer treatment approach owing to its non-invasiveness, spatiotemporal control and limited side effects. Currently, great efforts have been made to improve the PDT effect in terms of safety and efficiency. In this review, we highlight recent advances in innovative strategies for enhanced PDT, including (1) the development of novel radicals, (2) design of activatable photosensitizers based on the TME and light, and (3) photocatalytic NADH oxidation to damage the mitochondrial electron transport chain. Additionally, the new mechanisms for PDT are also presented as an inspiration for the design of novel PSs. Finally, we discuss the current challenges and future prospects in the clinical practice of these innovative strategies. It is hoped that this review will provide a new angle for understanding the relationship between the intratumoural redox environment and PDT mechanisms, and new ideas for the future development of smart PDT systems.
光动力疗法（PDT）因其非侵入性、时空可控性和副作用有限，已发展成为一种潜在的癌症治疗方法。目前，人们在提高PDT的安全性和效率方面做出了巨大努力。在这篇综述中，我们重点介绍了增强PDT创新策略的最新进展，包括（1）新型自由基的开发，（2）基于肿瘤微环境（TME）和光的可激活光敏剂的设计，以及（3）光催化NADH氧化以破坏线粒体电子传递链。此外，还介绍了PDT的新机制，为新型光敏剂（PSs）的设计提供灵感。最后，我们讨论了这些创新策略在临床实践中的当前挑战和未来前景。希望这篇综述能为理解肿瘤内氧化还原环境与PDT机制之间的关系提供一个新视角，并为智能PDT系统的未来发展提供新思路。
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