State Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing, 100190, P. R. China.
Center for Mesoscience, Institute of Process Engineering, Chinese Academy of Sciences, Beijing, 100190, P. R. China.
Adv Mater. 2017 Mar;29(12). doi: 10.1002/adma.201605021. Epub 2017 Jan 6.
Tremendous interest in self-assembly of peptides and proteins towards functional nanomaterials has been inspired by naturally evolving self-assembly in biological construction of multiple and sophisticated protein architectures in organisms. Self-assembled peptide and protein nanoarchitectures are excellent promising candidates for facilitating biomedical applications due to their advantages of structural, mechanical, and functional diversity and high biocompability and biodegradability. Here, this review focuses on the self-assembly of peptides and proteins for fabrication of phototherapeutic nanomaterials for antitumor photodynamic and photothermal therapy, with emphasis on building blocks, non-covalent interactions, strategies, and the nanoarchitectures of self-assembly. The exciting antitumor activities achieved by these phototherapeutic nanomaterials are also discussed in-depth, along with the relationships between their specific nanoarchitectures and their unique properties, providing an increased understanding of the role of peptide and protein self-assembly in improving the efficiency of photodynamic and photothermal therapy.
人们对肽和蛋白质自组装向功能性纳米材料的极大兴趣，受到了生物体中多种复杂蛋白质结构的自然进化自组装的启发。自组装的肽和蛋白质纳米结构由于其结构、机械和功能多样性以及高生物相容性和可生物降解性，是促进生物医学应用的优秀候选材料。在这里，本综述重点介绍了肽和蛋白质的自组装，用于制造光疗纳米材料，用于抗肿瘤光动力和光热治疗，重点介绍了构建块、非共价相互作用、策略和自组装的纳米结构。还深入讨论了这些光疗纳米材料所取得的令人兴奋的抗肿瘤活性，以及它们特定的纳米结构与其独特性质之间的关系，这为提高光动力和光热治疗的效率中肽和蛋白质自组装的作用提供了更深入的了解。
