Cave John W, Fujiwara Nana, Weibman Ava R, Baker Harriet
Burke Medical Research Institute, 785 Mamaroneck Avenue, White Plains, NY, USA.
The Feil Family Brain and Mind Research Institute, Weill Cornell Medical College, 1300 York Avenue, New York, NY, USA.
NPJ Parkinsons Dis. 2016 Jun 9;2:16011. doi: 10.1038/npjparkd.2016.11. eCollection 2016.
Olfactory dysfunction is associated with nearly all the cases of Parkinson's disease (PD) and typically manifests years before motor symptoms are detected. The cellular mechanisms underlying this dysfunction, however, are not understood. In this study, olfactory bulbs (OBs) from male control and PD subjects were examined by histology for changes in cytoarchitecture. These studies found that the general OB laminar organization and the number of interneurons expressing tyrosine hydroxylase were unaltered. In contrast, the number of mitral/tufted projection neurons and interneurons expressing Calretinin were significantly decreased in PD subjects. This study reveals changes in OB cytoarchitecture mediated by PD and provides valuable insight into identifying specific OB neuronal populations vulnerable to PD-related neurodegeneration.
嗅觉功能障碍几乎与所有帕金森病（PD）病例相关，并且通常在运动症状被检测到之前数年就已出现。然而，这种功能障碍背后的细胞机制尚不清楚。在本研究中，通过组织学检查了雄性对照和PD受试者的嗅球（OB），以观察细胞结构的变化。这些研究发现，OB的总体层状组织以及表达酪氨酸羟化酶的中间神经元数量未发生改变。相比之下，PD受试者中表达钙视网膜蛋白的二尖瓣/簇状投射神经元和中间神经元数量显著减少。这项研究揭示了由PD介导的OB细胞结构变化，并为识别易受PD相关神经退行性变影响的特定OB神经元群体提供了有价值的见解。
