Departamento de Psicobiologia, Universidade Federal de São Paulo, Napoleão de Barros, 925, Vila Clementino, São Paulo, SP, 04024-002, Brazil.
Departamento de Dermatologia, Universidade Federal de São Paulo, São Paulo, Brazil.
Arch Dermatol Res. 2017 Oct;309(8):659-664. doi: 10.1007/s00403-017-1765-9. Epub 2017 Jul 19.
Pemphigus is an autoimmune bullous disease that causes the development of blisters and erosions on the skin and/or mucosa. Its inflammatory process is mediated by cytokines, which interact with sleep in a bidirectional manner. Pain, a frequent symptom due to pemphigus lesions, is well known to impair sleep quality. Depression is also associated with pemphigus and pro-inflammatory cytokines and may impair sleep. Additionally, a common relationship among other dermatological diseases and sleep has increasingly been described. Poor sleep quality is associated with an increased risk for autoimmune diseases, and insomnia is a comorbidity that has recently been associated with pemphigus. Thus, this review will explore the evidence supporting the likely bidirectional relationship between pemphigus and sleep quality and its possible mechanisms involved. This approach covering both pemphigus and sleep will open a research avenue for future studies focusing on the efficacy of the sleep disorders treatment in patients with pemphigus. In the long term, this may provide relevant information to dermatologists regarding new strategies for the management of pemphigus clinical condition, allowing possibly a better quality of life for the patients.
天疱疮是一种自身免疫性大疱性疾病，可导致皮肤和/或黏膜出现水疱和糜烂。其炎症过程由细胞因子介导，这些细胞因子以双向方式与睡眠相互作用。疼痛是天疱疮病变的常见症状，众所周知会损害睡眠质量。抑郁也与天疱疮和促炎细胞因子有关，并可能影响睡眠。此外，其他皮肤病与睡眠之间的常见关系也越来越多地被描述。睡眠质量差与自身免疫性疾病的风险增加有关，失眠是一种最近与天疱疮相关的合并症。因此，本综述将探讨支持天疱疮与睡眠质量之间可能存在的双向关系及其可能涉及的机制的证据。这种涵盖天疱疮和睡眠的方法为未来专注于治疗天疱疮患者睡眠障碍疗效的研究开辟了研究途径。从长远来看，这可能为皮肤科医生提供有关管理天疱疮临床状况的新策略的相关信息，使患者有可能获得更好的生活质量。
