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Lipoxygenases modulate the effect of glutoxim on Na transport in the frog skin epithelium.

作者信息

Krutetskaya Z I, Melnitskaya A V, Antonov V G, Nozdrachev A D

机构信息

St. Petersburg State University, St. Petersburg, 199034, Russia.

出版信息

Dokl Biochem Biophys. 2017 May;474(1):193-195. doi: 10.1134/S1607672917030073. Epub 2017 Jul 20.

DOI:10.1134/S1607672917030073
PMID:28726099
Abstract

Using voltage-clamp technique, the involvement of lipoxygenases in the effect of immunomodulatory drug glutoxim on Na transport in frog skin was investigated. It was shown for the first time that preincubation of the skin with lipoxygenase inhibitors caffeic acid, baicalein, and nordihydroguaiaretic acid significantly decreases the stimulatory effect of glutoxim on Na transport. The data suggest the involvement of lipoxygenase oxidation pathway of arachidonic acid metabolism in the glutoxim effect on Na transport in frog skin epithelium.

摘要

相似文献

1
Lipoxygenases modulate the effect of glutoxim on Na transport in the frog skin epithelium.
Dokl Biochem Biophys. 2017 May;474(1):193-195. doi: 10.1134/S1607672917030073. Epub 2017 Jul 20.
2
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Epoxygenase Inhibitors Attenuate the Stimulatory Effect of Glutoxim on Na Transport in Frog Skin.环氧合酶抑制剂减弱谷胱甘肽对蛙皮钠转运的刺激作用。
Dokl Biochem Biophys. 2018 May;480(1):152-154. doi: 10.1134/S1607672918030079. Epub 2018 Jul 14.

本文引用的文献

1
Cytochrome P450 and Lipoxygenase Metabolites on Renal Function.细胞色素P450和脂氧合酶代谢产物对肾功能的影响
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2
Inhibitors of the cyclooxygenase oxidation pathway of arachidonic acid suppress the stimulating effect of glutoxim on Na(+) transport in frog skin.花生四烯酸环氧化酶氧化途径的抑制剂可抑制谷胱甘肽对蛙皮中Na(+)转运的刺激作用。
Dokl Biol Sci. 2013 Jul-Aug;451:193-5. doi: 10.1134/S0012496613040042. Epub 2013 Aug 24.
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