Krutetskaya Z I, Melnitskaya A V, Antonov V G, Nozdrachev A D
St. Petersburg State University, 199034, St. Petersburg, Russia.
Dokl Biochem Biophys. 2019 May;484(1):63-65. doi: 10.1134/S1607672919010186. Epub 2019 Apr 22.
Using voltage-clamp technique, the involvement of sigma-1 receptors in the regulation of Na transport in frog skin by the immunomodulatory drug glutoxim was investigated. We have shown for the first time that preincubation of the frog skin with the sigma-1 receptor antagonists haloperidol and chlorpromazine attenuates the stimulatory effect of glutoxim on the Na transport. The results suggest the possible involvement of the sigma-1 receptors in the regulation of Na transport in frog skin epithelium by glutoxim.
采用电压钳技术，研究了免疫调节药物谷胱甘肽在蛙皮钠转运调节中σ-1受体的参与情况。我们首次表明，用σ-1受体拮抗剂氟哌啶醇和氯丙嗪预孵育蛙皮可减弱谷胱甘肽对钠转运的刺激作用。结果表明，σ-1受体可能参与了谷胱甘肽对蛙皮上皮钠转运的调节。
