Sigma-1 Receptor Antagonists Haloperidol and Chlorpromazine Modulate the Effect of Glutoxim on Na Transport in Frog Skin.

Using voltage-clamp technique, the involvement of sigma-1 receptors in the regulation of Na transport in frog skin by the immunomodulatory drug glutoxim was investigated. We have shown for the first time that preincubation of the frog skin with the sigma-1 receptor antagonists haloperidol and chlorpromazine attenuates the stimulatory effect of glutoxim on the Na transport. The results suggest the possible involvement of the sigma-1 receptors in the regulation of Na transport in frog skin epithelium by glutoxim.