Krutetskaya Z I, Melnitskaya A V, Antonov V G, Nozdrachev A D
St. Petersburg State University, St. Petersburg, 199034, Russia.
Dokl Biochem Biophys. 2018 May;480(1):152-154. doi: 10.1134/S1607672918030079. Epub 2018 Jul 14.
Using voltage-clamp technique, the involvement of epoxygenases in immunomodulatory drug glutoxim regulation of Na transport in frog skin was investigated. We have shown for the first time that preincubation of the frog skin with epoxygenase inhibitors econazole or proadifen almost completely inhibits the stimulatory effect of glutoxim on Na transport. The data suggest the involvement of the enzymes and/or products of epoxygenase oxidation pathway of arachidonic acid metabolism in glutoxim effect on Na transport in frog skin epithelium.
采用电压钳技术，研究了环氧合酶在免疫调节药物谷胱甘肽对蛙皮钠转运的调节作用中的参与情况。我们首次表明，用环氧合酶抑制剂益康唑或丙胺卡因预孵育蛙皮几乎完全抑制了谷胱甘肽对钠转运的刺激作用。这些数据表明，花生四烯酸代谢的环氧合酶氧化途径的酶和/或产物参与了谷胱甘肽对蛙皮上皮钠转运的作用。
