Bygbjerg I C, Jepsen S, Theander T G
Acta Trop. 1986 Mar;43(1):55-62.
The peripheral blood lymphocyte response to affinity purified soluble Plasmodium falciparum antigens from in vitro cultures was studied in seven patients with acute falciparum malaria, on eight occasions, and in 15 persons having had malaria, at various times post infection, on 24 occasions. During infection, the response was low or absent in most patients (median stimulating index = [SI] = 1.4). One week post infection, a specific antigen response rose (SI = 2.9), but not to the levels found two weeks to one year post infection (SI = 5.8). At two to four years post infection, it was still present. During a recrudescence of malaria in a single patient, it was lost temporarily. The response to optimal concentrations of lectin mitogens and to tuberculin antigen was not suppressed in acute malaria.
对7例急性恶性疟患者进行了8次研究，观察其外周血淋巴细胞对体外培养的经亲和纯化的可溶性恶性疟原虫抗原的反应；同时对15例曾患疟疾的人在感染后的不同时间进行了24次观察。在感染期间，大多数患者的反应较低或无反应（中位刺激指数[SI]=1.4）。感染后1周，特异性抗原反应升高（SI=2.9），但未达到感染后2周至1年时的水平（SI=5.8）。在感染后2至4年，该反应仍然存在。在1例患者疟疾复发期间，该反应暂时消失。急性疟疾患者对最佳浓度的凝集素促有丝分裂原和结核菌素抗原的反应未受抑制。
