Shliakhtsitsava Ksenya, Romero Sally A D, Dewald Samantha Rose, Su H Irene
a Department of Pediatric Hematology and Oncology , University of California , San Diego , CA , USA.
b Department of Integrative Medicine , Memorial Sloan Kettering Cancer Center , New York , NY , USA.
Leuk Lymphoma. 2018 Feb;59(2):381-397. doi: 10.1080/10428194.2017.1352097. Epub 2017 Jul 21.
As long-term survival is high for children and young adults diagnosed with leukemia and lymphoma, delineating maternal, fetal and offspring health risks is important to their family planning. This systematic review examined data comparing these health risks between leukemia and lymphoma survivors and women without a history of cancer. Following a search of Embase, PubMed, CINAHL, Cochrane, and Web of Science, 142 articles were screened and 18 were included in this review. No higher risks of spontaneous abortion, maternal diabetes and anemia, stillbirth, birth defects, or childhood cancer in offspring were observed in survivors compared to controls. Important to counseling and clinical care, live birth rates were lower, while preterm birth and low birth weight risks were modestly higher in survivors compared to controls. Findings were largely reassuring but highlight the lack of data on maternal cardiopulmonary risks, differential risk by cancer treatment type, and interventions to decrease these risks.
由于被诊断患有白血病和淋巴瘤的儿童及年轻成年人长期生存率较高，明确母亲、胎儿及后代的健康风险对他们的计划生育至关重要。本系统综述研究了比较白血病和淋巴瘤幸存者与无癌症病史女性之间这些健康风险的数据。在检索了Embase、PubMed、CINAHL、Cochrane和科学网之后，筛选了142篇文章，其中18篇纳入本综述。与对照组相比，未观察到幸存者出现自然流产、母亲患糖尿病和贫血、死产、出生缺陷或后代患儿童癌症的风险更高。对咨询和临床护理很重要的是，与对照组相比，幸存者的活产率较低，而早产和低出生体重风险略高。研究结果在很大程度上令人安心，但突出了缺乏关于母亲心肺风险、癌症治疗类型的差异风险以及降低这些风险的干预措施的数据。
