Venegas Sanabria Luis Carlos, Barbosa Balaquera Stephany, Suarez Acosta Ana María, García Peña Ángel Alberto, Cano Gutiérrez Carlos Alberto
Pontificia Universidad Javeriana. Hospital Universitario San Ignacio, Unidad de Geriatría, Instituto de Envejecimiento. Semillero de investigación de Neurociencias y Envejecimiento, Bogotá, Colombia.
Pontificia Universidad Javeriana. Hospital Universitario San Ignacio, Unidad de Geriatría, Instituto de Envejecimiento. Semillero de investigación de Neurociencias y Envejecimiento, Bogotá, Colombia.
Rev Esp Geriatr Gerontol. 2017 Nov-Dec;52(6):317-321. doi: 10.1016/j.regg.2017.03.005. Epub 2017 Jul 17.
With the high incidence of cardiovascular events in the elderly population the effectiveness of statins in reducing mortality from coronary events has been demonstrated. However, there have been adverse effects, such as myalgia, myopathy, myonecrosis, not to mention the falls as a result of muscle damage with statin use.
The purpose of this study is to conduct a systematic review to assess the literature on the association between statin use and the risk of falls.
The databases that were included PUBMED AND SCOPUS, with articles published from January 2000 to May 2016. The MESH terms used for the search were "FALLS" AND "STATIN". Selected studies included cohort populations from the community (>50 years old), and analysed using the Scottish Intercollegiate (SIGN) methodology guidelines, as no randomised controlled study was found.
In the study by Ham et al., statin use was shown to be a protective factor for presence of falls. In the second study by Scott et al., there was an increased risk of falls (P=.029) and an impairment in muscle strength and quality muscle (P=.033 and P=.046, respectively). In the third study Haerer et al., found an increased risk of falls (P=.63).
The association between use of statins and risk of falls could not be determined with the available evidence, although an association with the involvement of some determinants of muscular function was found.
随着老年人群心血管事件的高发病率，他汀类药物在降低冠状动脉事件死亡率方面的有效性已得到证实。然而，也存在一些不良反应，如肌痛、肌病、肌坏死，更不用说因使用他汀类药物导致肌肉损伤而引起的跌倒了。
本研究的目的是进行一项系统评价，以评估关于使用他汀类药物与跌倒风险之间关联的文献。
纳入的数据库有PUBMED和SCOPUS，检索2000年1月至2016年5月发表的文章。检索使用的医学主题词为“跌倒”和“他汀类药物”。选定的研究包括来自社区（年龄>50岁）的队列人群，并按照苏格兰校际间（SIGN）方法指南进行分析，因为未找到随机对照研究。
在Ham等人的研究中，使用他汀类药物被证明是跌倒存在的一个保护因素。在Scott等人的第二项研究中，跌倒风险增加（P = 0.029），肌肉力量和肌肉质量受损（分别为P = 0.033和P = 0.046）。在第三项研究Haerer等人中，发现跌倒风险增加（P = 0.63）。
尽管发现他汀类药物的使用与一些肌肉功能决定因素的参与有关，但现有证据无法确定他汀类药物的使用与跌倒风险之间的关联。
