Kvæl Linda Aimée Hartford, Bergland Astrid, Telenius Elisabeth Wiken
Department of Physiotherapy, Faculty of Health Sciences, Oslo and Akershus University College of Applied Sciences, Oslo, Norway.
Ryen Helsehus/Short-term Rehabilitation, Nursing Home Agency, Oslo, Norway.
BMJ Open. 2017 Jul 20;7(7):e016875. doi: 10.1136/bmjopen-2017-016875.
The primary aim of this study is to describe depression and physical function in nursing home residents with dementia, as well as to examine the associations between depression and balance function, lower limb muscle strength, mobility and activities of daily living. The secondary aim is to examine the differences in physical function between the groups classified as depressed and not depressed.
The study has a cross-sectional design.
A convenience sample of 18 nursing homes in, and around, Oslo, Norway, participated.
We included 170 nursing home residents aged 60-100 years with mild or moderate degree of dementia defined by a score of 1 or 2 on the Clinical Dementia Rating Scale (CDR).
Assessments used were Cornell Scale for Depression in Dementia (CSDD), Berg Balance Scale (BBS), 'the 6-metre walking test' (walking speed), 30 s Chair Stand Test (CST) and the Barthel Index (BI).
Nursing home residents with dementia are a heterogeneous group in terms of physical function and depression. By applying the recommended cut-off of ≥8 on CSDD, 23.5% of the participants were classified as being depressed. The results revealed significant associations between higher scores on CSDD (indicating more symptoms of depression) and lower scores on BBS (95% CI -0.12 to -0.02, p=0.006), 30 s CST (95% CI -0.54 to -0.07, p=0.001) as well as maximum walking speed (95% CI -4.56 to -0.20, p=0.003) (indicating lower level of physical function).
Better muscle strength, balance and higher walking speed were significantly associated with less depressive symptoms. The potential interaction of dementia with poor physical function and depression indicates an area to explore in future epidemiological studies with a prospective design.
NCT02262104.
本研究的主要目的是描述患有痴呆症的养老院居民的抑郁状况和身体功能，同时研究抑郁与平衡功能、下肢肌肉力量、活动能力和日常生活活动之间的关联。次要目的是研究抑郁组和非抑郁组在身体功能上的差异。
本研究采用横断面设计。
挪威奥斯陆及其周边地区的18家养老院组成的便利样本参与了研究。
我们纳入了170名年龄在60 - 100岁之间、临床痴呆评定量表（CDR）评分为1或2分，患有轻度或中度痴呆症的养老院居民。
所使用的评估方法包括痴呆抑郁量表（CSDD）、伯格平衡量表（BBS）、“6米步行测试”（步行速度）、30秒坐立试验（CST）和巴氏指数（BI）。
患有痴呆症的养老院居民在身体功能和抑郁方面是一个异质性群体。按照CSDD推荐的≥8分的临界值，23.5%的参与者被归类为抑郁。结果显示，CSDD得分较高（表明抑郁症状较多）与BBS得分较低（95%CI -0.12至 -0.02，p = 0.006）、30秒CST得分较低（95%CI -0.54至 -0.07，p = 0.001）以及最大步行速度较低（95%CI -4.56至 -0.20，p = 0.003）（表明身体功能水平较低）之间存在显著关联。
更好的肌肉力量、平衡能力和更高的步行速度与较少的抑郁症状显著相关。痴呆症与身体功能差和抑郁之间的潜在相互作用表明，这是未来前瞻性设计的流行病学研究中需要探索的一个领域。
NCT02262104。
