el-Sharabasy M M, el-Dosoky I
Br J Urol. 1986 Jun;58(3):279-82. doi: 10.1111/j.1464-410x.1986.tb09054.x.
The value of hydrolytic enzymes in 29 specimens of human bladder cancer has been assessed. Acid and alkaline phosphatases, gamma-glutamyl transferase, arylsulphatases and lactate dehydrogenase were estimated in human bladder tumours and adjacent non-malignant tissue. Elevated enzyme levels were observed in the tumours rather than in the non-malignant tissue, except for adenocarcinoma. These increased levels were also noted in bilharzial bladder carcinoma but not in lymph node metastasis. Increased enzyme activity could be due to over-production by the tumour cells. It was concluded that the increase was associated primarily with the presence of tumours and the assay of these enzymes in biopsy specimens may have significant diagnostic and therapeutic implications.
对29例人类膀胱癌标本中的水解酶价值进行了评估。对人类膀胱肿瘤及相邻的非恶性组织中的酸性和碱性磷酸酶、γ-谷氨酰转移酶、芳基硫酸酯酶和乳酸脱氢酶进行了测定。除腺癌外，肿瘤中的酶水平升高，而非恶性组织中未升高。在血吸虫性膀胱癌中也观察到这些升高的水平，但在淋巴结转移中未观察到。酶活性增加可能是由于肿瘤细胞过度产生。得出的结论是，这种增加主要与肿瘤的存在有关，在活检标本中检测这些酶可能具有重要的诊断和治疗意义。
