Baranovskiy Andrey G, Babayeva Nigar D, Zhang Yinbo, Blanco Luis, Pavlov Youri I, Tahirov Tahir H
Eppley Institute for Research in Cancer and Allied Diseases, Fred and Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE 68198, USA.
Department of Immunology, University of Washington, Seattle WA 98195, USA.
Science. 2017 Jul 21;357(6348). doi: 10.1126/science.aan2396.
O'Brien (Research Article, 24 February 2017, eaag1789) proposed a novel mechanism of primase function based on redox activity of the iron-sulfur cluster buried inside the C-terminal domain of the large primase subunit (p58C). Serious problems in the experimental design and data interpretation raise concerns about the validity of the conclusions.
奥布赖恩（研究文章，2017年2月24日，eaag1789）基于埋藏在大型引发酶亚基（p58C）C末端结构域内的铁硫簇的氧化还原活性，提出了一种引发酶功能的新机制。实验设计和数据解读中的严重问题引发了对这些结论有效性的担忧。
