Meryn S, Spigland I, Bauman W A
Clin Immunol Immunopathol. 1986 Aug;40(2):291-7. doi: 10.1016/0090-1229(86)90033-4.
The prevalence and titer of antibodies to pancreatic hormones in 21 diabetics treated with USP insulin preparations before 1964 (Group 1) and in another 21 diabetics treated with more highly purified insulin preparations after 1974 (Group 2) were determined. All subjects in Group 1 had antibodies to insulin, 11 had antibodies to pancreatic polypeptide (PP) and 3 to glucagon. In Group 2, 17 had antibodies to insulin, 5 to PP, and 1 to glucagon. Antibodies to somatostatin (SRIF) were not detectable in either group. Group 1 subjects had higher titers of antibodies to insulin, glucagon, and PP than Group 2 subjects. Of note, the Group 1 subjects with the highest insulin antibodies also had the greatest prevalence and highest titers of antibodies to glucagon and PP. In order to address the question of possible differences in immune responsivity between Group 1 and 2 subjects, antibody titers to 4 ubiquitous viral agents were determined. There was no significant difference in viral antibody titers between the groups.
测定了1964年前接受美国药典胰岛素制剂治疗的21名糖尿病患者（第1组）和1974年后接受更高纯度胰岛素制剂治疗的另外21名糖尿病患者（第2组）中胰腺激素抗体的患病率和滴度。第1组的所有受试者均有胰岛素抗体，11人有胰多肽（PP）抗体，3人有胰高血糖素抗体。在第2组中，17人有胰岛素抗体，5人有PP抗体，1人有胰高血糖素抗体。两组中均未检测到生长抑素（SRIF）抗体。第1组受试者的胰岛素、胰高血糖素和PP抗体滴度高于第2组受试者。值得注意的是，胰岛素抗体最高的第1组受试者中，胰高血糖素和PP抗体的患病率和滴度也最高。为了解决第1组和第2组受试者之间免疫反应性可能存在差异的问题，测定了针对4种普遍存在的病毒制剂的抗体滴度。两组之间的病毒抗体滴度没有显著差异。
